SCHEMBL6561912

SCHEMBL6561912

[CH2]C(=O)N(CC)N1C(=O)C=CC1=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.37
MGLL Q99685 4/20 0.37
BLM P54132 2/20 0.37
NPSR1 Q6W5P4 2/20 0.37
GMNN O75496 1/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
THPO P40225 1/20 0.37
PMP22 Q01453 1/20 0.37
HPGD P15428 3/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
WRN Q14191 1/20 0.36
HIF1A Q16665 1/20 0.36
GSK3A P49840 2/20 0.35
GSK3B P49841 2/20 0.35
HSP90AA1 P07900 2/20 0.31
HTT P42858 2/20 0.31
XBP1 P17861 1/20 0.31
ALOX12 P18054 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29279039 0.73 NFKB1 (0.43) ALDH1A1MGLLBLMNPSR1GMNN
SCHEMBL28022264 0.72 MGLL (0.37) ALDH1A1MGLLBLMNPSR1GMNN
SCHEMBL16588917 0.69 KDM4E (0.39) ALDH1A1GSK3AGSK3BHTTCACNA1B
SCHEMBL3694475 0.64 PTGS1 (0.36) ALDH1A1MGLLLMNAMAPTHPGD
SCHEMBL6730017 0.64 ALDH1A1 (0.40) ALDH1A1MGLLBLMNPSR1GMNN
SCHEMBL5112834 0.63 L3MBTL1 (0.31) TDP1
SCHEMBL23649967 0.62 ALDH1A1 (0.35) ALDH1A1MGLLBLMNPSR1GMNN
SCHEMBL19665269 0.61 MGLL (0.42) ALDH1A1MGLLBLMNPSR1GMNN
Hydrochloric Acid SCHEMBL28493006 0.60 GSK3A (0.36) ALDH1A1MGLLBLMNPSR1GMNN
SCHEMBL4890528 0.60

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0931062-B1 CONJUGATES AND SPECIFIC IMMUNOASSAYS FOR THE METHADONE METABOLITE 2-ETHYLIDINE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE MICROGENICS CORP (US) 2004-11-17 EP disclosed
US-6140137-A METABOLITE LINKED TO POLYPEPTIDE FOR ANALYSIS AND ANTIBODY PRODUCTION; MONITORING COMPLIANCE WITH METHADONE TREATMENT MICROGENICS CORPORATION (US) 2000-10-31 US disclosed
EP-0931062-A1 CONJUGATES AND SPECIFIC IMMUNOASSAYS FOR THE METHADONE METABOLITE 2-ETHYLIDINE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE MICROGENICS CORPORATION (US) 1999-07-28 EP disclosed
WO-1998054133-A1 CONJUGATES AND SPECIFIC IMMUNOASSAYS FOR THE METHADONE METABOLITE 2-ETHYLIDINE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE MICROGENICS CORPORATION (US) 1998-12-03 WO disclosed