Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 8/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | ITGAL | P20701 | 1/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671224 | 0.90 | PRSS1 (0.35) | MEN1KMT2ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL6561843 | 0.85 | GAA (0.31) | MEN1KMT2ATSHRSMN1; SMN2NAMPT | |
| SCHEMBL7669679 | 0.81 | F2 (0.37) | MEN1KMT2AMAPK1ALDH1A1HTT | |
| SCHEMBL6563261 | 0.72 | HSD11B1 (0.38) | ALDH1A1MAPTHTTNAMPT | |
| SCHEMBL6565512 | 0.71 | GAA (0.40) | MEN1KMT2AMAPK1ALDH1A1NAMPT | |
| SCHEMBL7804851 | 0.70 | HRH3 (0.36) | — | |
| SCHEMBL7806152 | 0.69 | HRH3 (0.37) | ALDH1A1 | |
| SCHEMBL6561835 | 0.69 | PTPN11 (0.35) | MEN1KMT2AALDH1A1MAPTKCNK3 | |
| SCHEMBL6563696 | 0.68 | HPGD (0.37) | MEN1KMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL6565856 | 0.68 | IMPDH2 (0.38) | MEN1KMT2ATSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |