Sugi Predict

Sugi Predict / Compounds / SCHEMBL6563462

SCHEMBL6563462

SCHEMBL6563462

Nc1ccc(Cl)c(S(=O)(=O)NCCOCc2ccccc2)c1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CXCR2 P25025 2/20 0.46
▸ ALDH1A1 P00352 2/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.38
▸ HTT P42858 1/20 0.38
▸ ACLY P53396 2/20 0.36
▸ LMNA P02545 2/20 0.36
▸ PRMT1 Q99873 2/20 0.35
▸ CXCR1 P25024 1/20 0.35
▸ NSD2 O96028 2/20 0.34
▸ CA12 O43570 1/20 0.34
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ CA9 Q16790 1/20 0.34
▸ PRKACA P17612 1/20 0.34
▸ PRKACG P22612 1/20 0.34
▸ PRKACB P22694 1/20 0.34
▸ AKT2 P31751 1/20 0.34
▸ SLC12A2 P55011 1/20 0.34
▸ SLC12A5 Q9H2X9 1/20 0.34
▸ TP53 P04637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6563454 0.83 CXCR2 (0.44) CXCR2ALDH1A1SMN1; SMN2HTTACLY
SCHEMBL6565699 0.82 VCAM1 (0.45) CXCR2ALDH1A1SMN1; SMN2HTTLMNA
SCHEMBL6563961 0.81 LMNA (0.51) ALDH1A1LMNAPRMT1NSD2CA12
SCHEMBL6565584 0.80 CXCR2 (0.56) CXCR2ALDH1A1SMN1; SMN2HTTLMNA
SCHEMBL6564162 0.78 CXCR2 (0.60) CXCR2LMNACXCR1
SCHEMBL4586947 0.78 CXCR2 (0.60) CXCR2CXCR1
SCHEMBL6563387 0.77 CXCR2 (0.43) CXCR2ALDH1A1SMN1; SMN2HTTLMNA
SCHEMBL6562115 0.77 GSTO1 (0.43) CXCR2ALDH1A1GAAL3MBTL1
SCHEMBL27552122 0.76 FABP4 (0.42) CXCR2ALDH1A1CA1CA2
SCHEMBL6565726 0.76 CA12 (0.46) CXCR2ALDH1A1SMN1; SMN2HTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1161232-B1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2004-03-24 — — EP disclosed
US-20030109527-A1 Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists SMITHKLINE BEECHAM CORPORATION 2003-06-12 — — US disclosed
US-6500863-B1 INTERLEUKIN BINDING INHIBITORS SUCH AS N-(2-HYDROXYL-3-AMINO SULFONYL-4-CHLOROPHENYL)-N'-(2-BROMOPHENYL)UREA, USED FOR PROPHYLAXIS OF CHEMOKINE MEDIATED DISEASES SMITHKLINE BEECHAM CORPORATION 2002-12-31 — — US disclosed
EP-1161232-A4 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2002-09-18 — — EP disclosed
CN-1334726-A Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-02-06 — — CN disclosed
EP-1161232-A1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2001-12-12 — — EP disclosed
WO-2000035442-A1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030109527-A1 Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists CXCL8, CCR8, IL18 CXCR2 26/4885ALDH1A1 1321/4885SMN1; SMN2 4398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.