Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 9/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPN | P05981 | 3/20 | 0.35 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563563 | 0.93 | SMN1; SMN2 (0.38) | PLAUF2KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL6563711 | 0.86 | ADAM17 (0.47) | KEAP1NFE2L2 | |
| SCHEMBL6564229 | 0.82 | F2 (0.43) | F2HPN | |
| SCHEMBL6563331 | 0.80 | F2 (0.43) | F2 | |
| SCHEMBL6563704 | 0.80 | KEAP1 (0.34) | KEAP1NFE2L2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL6563611 | 0.80 | ITGB3 (0.38) | PLAUF2 | |
| SCHEMBL7676372 | 0.80 | F2 (0.43) | F2 | |
| SCHEMBL6564165 | 0.79 | F2 (0.41) | PLAUF2HPN | |
| SCHEMBL6562287 | 0.79 | F2 (0.41) | F2 | |
| SCHEMBL6562064 | 0.79 | ADAM17 (0.43) | F2KEAP1NFE2L2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |