Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.43 |
| ▸ | MMP13 | P45452 | 13/20 | 0.43 |
| ▸ | MMP9 | P14780 | 11/20 | 0.43 |
| ▸ | MMP1 | P03956 | 8/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563711 | 0.92 | ADAM17 (0.47) | ADAM17MMP13MMP9MMP1KEAP1 | |
| SCHEMBL6565355 | 0.85 | F2 (0.42) | LTA4HF2F10 | |
| SCHEMBL6563563 | 0.81 | SMN1; SMN2 (0.38) | MMP13MMP9MMP1KEAP1NFE2L2 | |
| SCHEMBL6565338 | 0.81 | F2 (0.36) | LTA4HF2F10 | |
| SCHEMBL6563579 | 0.80 | F2 (0.37) | F2F10 | |
| SCHEMBL6563500 | 0.79 | PLAU (0.40) | KEAP1NFE2L2MAPTF2 | |
| SCHEMBL6563619 | 0.76 | F2 (0.41) | ADAM17MMP13MMP9MMP1F2 | |
| SCHEMBL6562325 | 0.75 | PRSS1 (0.36) | ADAM17MMP13MMP9MMP1F2 | |
| SCHEMBL6563233 | 0.73 | TMPRSS15 (0.38) | ADAM17MMP13MMP9MMP1F2 | |
| SCHEMBL6565497 | 0.71 | PLAU (0.48) | ADAM17MMP13MMP9MMP1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |