Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.47 |
| ▸ | MMP13 | P45452 | 17/20 | 0.47 |
| ▸ | MMP9 | P14780 | 15/20 | 0.47 |
| ▸ | MMP1 | P03956 | 9/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562064 | 0.92 | ADAM17 (0.43) | ADAM17MMP13MMP9MMP1KEAP1 | |
| SCHEMBL6563500 | 0.86 | PLAU (0.40) | KEAP1NFE2L2 | |
| SCHEMBL6563619 | 0.84 | F2 (0.41) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6563563 | 0.82 | SMN1; SMN2 (0.38) | MMP13MMP9MMP1KEAP1NFE2L2 | |
| SCHEMBL6563233 | 0.80 | TMPRSS15 (0.38) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6562325 | 0.79 | PRSS1 (0.36) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6565355 | 0.76 | F2 (0.42) | — | |
| SCHEMBL6565497 | 0.73 | PLAU (0.48) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6563579 | 0.73 | F2 (0.37) | — | |
| SCHEMBL6565338 | 0.72 | F2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |