Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.66 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24732382 | 0.86 | KDR (0.73) | TRPV1MEN1KMT2AKDM4ETP53 | |
| SCHEMBL7759976 | 0.85 | MEN1 (0.68) | TRPV1MEN1KMT2AKDM4ETP53 | |
| SCHEMBL2266591 | 0.82 | KMT2A (0.56) | TRPV1MEN1KMT2AKDM4ETP53 | |
| SCHEMBL6565538 | 0.80 | NPC1 (0.59) | TRPV1MEN1KMT2AKDM4ETP53 | |
| SCHEMBL22567818 | 0.79 | KDR (0.60) | TRPV1MEN1KMT2AKDM4EGRIK1 | |
| SCHEMBL9400341 | 0.79 | ALDH1A1 (0.70) | TRPV1BAZ1AMEN1KMT2AMAOB | |
| SCHEMBL6567619 | 0.79 | KMT2A (0.65) | TRPV1MEN1KMT2AKDM4EGRIK1 | |
| SCHEMBL5612816 | 0.78 | MEN1 (0.58) | TRPV1MEN1KMT2AKDM4EMAOB | |
| SCHEMBL7098404 | 0.78 | TP53 (0.68) | TRPV1BAZ1AMEN1KMT2AMAOB | |
| SCHEMBL3946302 | 0.78 | BAZ1A (1.00) | TRPV1BAZ1AMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |