SCHEMBL6567404

SCHEMBL6567404

Cc1c(O)cc(O)c2c(=O)c(O)c(-c3ccc(O)cc3)oc12

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 2/20 0.76
BCL9 O00512 4/20 0.62
CTNNB1 P35222 4/20 0.62
ABCB1 P08183 7/20 0.59
ALDH1A1 P00352 3/20 0.59
KDM4E B2RXH2 2/20 0.59
MEN1 O00255 2/20 0.59
SLCO2B1 O94956 2/20 0.59
MAPT P10636 2/20 0.59
HPGD P15428 2/20 0.59
ALOX15 P16050 2/20 0.59
DAPK1 P53355 2/20 0.59
KMT2A Q03164 2/20 0.59
CDK1 P06493 2/20 0.59
CCNB1 P14635 2/20 0.59
CYP1A1 P04798 2/20 0.59
CYP1A2 P05177 2/20 0.59
CYP1B1 Q16678 2/20 0.59
FTO Q9C0B1 2/20 0.59
CA12 O43570 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13857095 0.87 MEN1 (0.77) FBP1BCL9CTNNB1ABCB1ALDH1A1
SCHEMBL29575800 0.87 MEN1 (0.77) FBP1BCL9CTNNB1ABCB1ALDH1A1
Herbacetin SCHEMBL872691 0.87 FBP1 (1.00) FBP1BCL9CTNNB1ABCB1ALDH1A1
Herbacetin SCHEMBL31442430 0.87 FBP1 (1.00) FBP1BCL9CTNNB1ABCB1ALDH1A1
SCHEMBL12640012 0.85 MAPT (0.61) FBP1BCL9CTNNB1ABCB1ALDH1A1
SCHEMBL1608916 0.82 FBP1 (0.71) FBP1BCL9CTNNB1ABCB1ALDH1A1
SCHEMBL30095422 0.82 FBP1 (0.71) FBP1BCL9CTNNB1ABCB1ALDH1A1
SCHEMBL16682485 0.81 FBP1 (0.78) FBP1BCL9CTNNB1ABCB1ALDH1A1
SCHEMBL26204956 0.81 FBP1 (0.78) FBP1BCL9CTNNB1ABCB1ALDH1A1
SCHEMBL31026217 0.80 MEN1 (0.68) FBP1BCL9CTNNB1ABCB1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220281903-A1 FLAVONOID DERIVATIVE FOR TREATING DENTAL CARIES MÜHLBAUER TECHNOLOGY GMBH (DE) 2022-09-08 US claimed
EP-4017585-A1 FLAVONOID DERIVATIVE FOR TREATING DENTAL CARIES Mühlbauer Technology GmbH (DE) 2022-06-29 EP claimed
WO-2021032844-A1 FLAVONOID DERIVATIVE FOR TREATING DENTAL CARIES MÜHLBAUER TECHNOLOGY GMBH (DE) 2021-02-25 WO claimed
US-20040057908-A1 Oral compositions and use thereof NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2004-03-25 US claimed
EP-1399119-A2 ORAL COMPOSITIONS AND USE THEREOF University of Rochester (US) 2004-03-24 EP claimed
WO-2002047615-A2 ORAL COMPOSITIONS AND USE THEREOF UNIVERSITY OF ROCHESTER (US) 2002-06-20 WO claimed
US-12590111-B2 Flavonoid derivative for treating dental caries MÜHLBAUER TECHNOLOGY GMBH (DE) 2026-03-31 US disclosed
US-20240156877-A1 COMPOSITIONS AND USES THEREFOR MELCARE MEDICAL PTY LTD (AU) 2024-05-16 US disclosed
EP-4368178-A1 COMPOSITIONS OF HONEY AND GLUCONIC ACID AND USES THEREFOR Melcare Medical Pty Ltd (AU) 2024-05-15 EP disclosed
CN-118001410-A Composition and use thereof 麦尔凯亚医学股份有限公司 2024-05-10 CN disclosed
US-20220281903-A1 FLAVONOID DERIVATIVE FOR TREATING DENTAL CARIES MÜHLBAUER TECHNOLOGY GMBH (DE) 2022-09-08 US disclosed
EP-4017585-A1 FLAVONOID DERIVATIVE FOR TREATING DENTAL CARIES Mühlbauer Technology GmbH (DE) 2022-06-29 EP disclosed
US-11154578-B2 Compositions and methods of use MELGARE MEDICAL PTY LTD (AU) 2021-10-26 US disclosed
WO-2021032844-A1 FLAVONOID DERIVATIVE FOR TREATING DENTAL CARIES MÜHLBAUER TECHNOLOGY GMBH (DE) 2021-02-25 WO disclosed
US-20170209500-A1 COMPOSITIONS AND METHODS OF USE MELCARE MEDICAL PTY LTD (AU) 2017-07-27 US disclosed
WO-2016011498-A1 COMPOSITIONS AND METHODS OF USE MELCARE MEDICAL PTY LTD (AU) 2016-01-28 WO disclosed
US-20040057908-A1 Oral compositions and use thereof NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2004-03-25 US disclosed
EP-1399119-A2 ORAL COMPOSITIONS AND USE THEREOF University of Rochester (US) 2004-03-24 EP disclosed
WO-2002047615-A2 ORAL COMPOSITIONS AND USE THEREOF UNIVERSITY OF ROCHESTER (US) 2002-06-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220281903-A1 FLAVONOID DERIVATIVE FOR TREATING DENTAL CARIES ITGA8, ITGAL, ITGB2 FBP1 1395/4885BCL9 1811/4885CTNNB1 1961/4885
US-12590111-B2 Flavonoid derivative for treating dental caries ITGA8, ICAM1, ITGA2 FBP1 443/4885BCL9 1472/4885CTNNB1 4442/4885
US-20040057908-A1 Oral compositions and use thereof UGGT1, DPM1, B4GALT1 FBP1 359/4885BCL9 3354/4885CTNNB1 4188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.