Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 3/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CD74 | P04233 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15430010 | 0.81 | MAPT (0.59) | MAPTL3MBTL1TDP1ALDH1A1PPARD | |
| SCHEMBL6565718 | 0.80 | ALDH1A1 (0.51) | MAPTL3MBTL1ALDH1A1NPC1RAB9A | |
| SCHEMBL6567198 | 0.79 | LOXL2 (0.48) | MAPTALDH1A1POLBKDM4ENPC1 | |
| SCHEMBL14765480 | 0.79 | L3MBTL1 (0.53) | MAPTL3MBTL1TDP1ALDH1A1NPSR1 | |
| SCHEMBL6568646 | 0.74 | KDM4E (0.61) | MAPTALDH1A1POLBKDM4ENPC1 | |
| SCHEMBL12081673 | 0.73 | POLB (0.70) | MAPTL3MBTL1ALDH1A1PPARDPPARA | |
| SCHEMBL6565582 | 0.73 | ALDH1A1 (0.43) | MAPTL3MBTL1ALDH1A1POLBKDM4E | |
| SCHEMBL7478013 | 0.72 | PPARD (0.58) | MAPTL3MBTL1TDP1PPARDPPARA | |
| SCHEMBL6568655 | 0.72 | CNR2 (0.50) | MAPTL3MBTL1TDP1ALDH1A1POLB | |
| SCHEMBL13484544 | 0.71 | PPARD (0.53) | MAPTL3MBTL1ALDH1A1NPSR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |