SCHEMBL6573203

SCHEMBL6573203

COCCN(CCOC)c1ccc(N)c(-c2ccccc2F)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.34
ALOX15 P16050 1/20 0.34
HSD17B10 Q99714 1/20 0.34
BACE1 P56817 1/20 0.34
S100B P04271 1/20 0.33
SLC6A9 P48067 1/20 0.33
MAPT P10636 3/20 0.33
MBNL1 Q9NR56 1/20 0.33
F2 P00734 1/20 0.32
PRSS1 P07477 1/20 0.32
PRSS2 P07478 1/20 0.32
PRSS3 P35030 1/20 0.32
CRHR1 P34998 1/20 0.32
BTK Q06187 1/20 0.32
GBA1 P04062 1/20 0.32
MEN1 O00255 1/20 0.31
GAA P10253 1/20 0.31
HTT P42858 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6572101 0.89 CRHR1 (0.36) BACE1S100BF2PRSS1PRSS2
SCHEMBL6572636 0.86 CRHR1 (0.34) S100BF2PRSS1PRSS2PRSS3
SCHEMBL6572502 0.86 S100B (0.40) ALDH1A1ALOX15HSD17B10BACE1S100B
SCHEMBL6571532 0.85 HTR7 (0.44) ALDH1A1HSD17B10MAPTMEN1KMT2A
SCHEMBL6570863 0.85 CRHR1 (0.39) ALDH1A1BACE1S100BSLC6A9MAPT
SCHEMBL6571124 0.85 F2 (0.36) ALDH1A1S100BF2PRSS1PRSS2
SCHEMBL6572540 0.83 S100B (0.34) HSD17B10S100BF2PRSS1PRSS2
SCHEMBL6572343 0.83 CYP1A2 (0.40) ALDH1A1ALOX15HSD17B10BACE1F2
SCHEMBL6571801 0.82 ALDH1A1 (0.37) ALDH1A1S100BF2PRSS1PRSS2
SCHEMBL6572909 0.81 MAPT (0.40) ALDH1A1HSD17B10BACE1S100BMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed