Acetoacetic Acid

Acetoacetic Acid

SCHEMBL6572214

CC(=O)CC(=O)O.CC(=O)CC(=O)O.CC(O)CCO

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.38
GABRP O00591 2/20 0.37
GABRD O14764 2/20 0.37
GABRA1 P14867 2/20 0.37
GABRB1 P18505 2/20 0.37
GABRG2 P18507 2/20 0.37
GABRB3 P28472 2/20 0.37
GABRA5 P31644 2/20 0.37
GABRA3 P34903 2/20 0.37
GABRA2 P47869 2/20 0.37
GABRB2 P47870 2/20 0.37
GABRA4 P48169 2/20 0.37
GABRE P78334 2/20 0.37
GABRA6 Q16445 2/20 0.37
GABRG1 Q8N1C3 2/20 0.37
GABRG3 Q99928 2/20 0.37
GABRQ Q9UN88 2/20 0.37
KDM4E B2RXH2 1/20 0.37
KDM6B O15054 1/20 0.37
KDM5C P41229 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetoacetic Acid SCHEMBL8843224 1.00 ALDH1A1 (0.38) ALDH1A1GABRPGABRDGABRA1GABRB1
Acetoacetic Acid SCHEMBL28466057 0.98 ALDH1A1 (0.36) ALDH1A1GABRPGABRDGABRA1GABRB1
Acetoacetic Acid SCHEMBL8751686 0.89 ALDH1A1 (0.41) ALDH1A1GABRPGABRDGABRA1GABRB1
Acetoacetic Acid SCHEMBL1638934 0.84 TDP1 (0.46) ALDH1A1KDM4EKDM6BKDM5CEGLN1
Acetoacetic Acid SCHEMBL1640437 0.84 TDP1 (0.46) ALDH1A1KDM4EKDM6BKDM5CEGLN1
Acetoacetic Acid SCHEMBL18154854 0.84 ALDH1A1 (0.43) ALDH1A1GABRPGABRDGABRA1GABRB1
Acetoacetic Acid SCHEMBL1058961 0.84 TDP1 (0.50) ALDH1A1KDM4EKDM6BKDM5CEGLN1
Acetoacetic Acid SCHEMBL28640192 0.84 TDP1 (0.50) ALDH1A1KDM4EKDM6BKDM5CEGLN1
Acetoacetic Acid SCHEMBL5797078 0.84 TDP1 (0.50) ALDH1A1KDM4EKDM6BKDM5CEGLN1
1,3-Butanediol SCHEMBL2195943 0.84 TDP1 (0.40) ALDH1A1GABRPGABRDGABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304523-A1 COMBINED LACTATE AND KETONE BODY ESTERS FOR MEDICAL AND NUTRITIONAL USE AARHUS UNIVERSITET (DK) 2025-10-02 US claimed
US-20230399288-A1 LACTATE/KETONE BODY ESTERS AARHUS UNIVERSITET (DK) 2023-12-14 US claimed
US-20230285348-A1 COMPOSITIONS AND METHODS FOR WEIGHT LOSS MAINTENANCE UNIVERSITY OF SOUTH FLORIDA 2023-09-14 US claimed
EP-4240345-A1 LACTATE/KETONE BODY ESTERS Aarhus Universitet (DK) 2023-09-13 EP claimed
CN-116528848-A Lactic acid/ketone body esters 奥胡斯大学 2023-08-01 CN claimed
US-11596616-B2 Compositions and methods for weight loss maintenance UNIVERSITY OF SOUTH FLORIDA (US) 2023-03-07 US claimed
WO-2022096637-A1 LACTATE/KETONE BODY ESTERS AARHUS UNIVERSITET (DK) 2022-05-12 WO claimed
US-20200397736-A1 COMPOSITIONS AND METHODS FOR WEIGHT LOSS MAINTENANCE UNIVERSITY OF SOUTH FLORIDA 2020-12-24 US claimed
US-20250304523-A1 COMBINED LACTATE AND KETONE BODY ESTERS FOR MEDICAL AND NUTRITIONAL USE AARHUS UNIVERSITET (DK) 2025-10-02 US disclosed
EP-4595775-A2 BHB-CITRATE COMBINATION PRODUCTS FOR RENAL HEALTH AND TREATING DISEASE The Regents of the University of California (US) 2025-08-06 EP disclosed
EP-4519239-A1 COMBINED LACTATE AND KETONE BODY ESTERS FOR MEDICAL AND NUTRITIONAL USE Aarhus Universitet (DK) 2025-03-12 EP disclosed
US-20240157322-A1 CROSSLINKED CORE-SHELL MICROCAPSULES FIRMENICH SA (CH) 2024-05-16 US disclosed
US-20240149237-A1 ACETOACETYL POLYMER - BASED MICROCAPSULES FIRMENICH SA (CH) 2024-05-09 US disclosed
EP-4313393-A1 CROSSLINKED CORE-SHELL MICROCAPSULES Firmenich SA (CH) 2024-02-07 EP disclosed
EP-1009377-A1 MEDICAL USES OF PYRUVATES Case Western Reserve University (US) 2000-06-21 EP disclosed
WO-1998051277-A1 MEDICAL USES OF PYRUVATES CASE WESTERN RESERVE UNIVERSITY (US) 1998-11-19 WO disclosed
EP-0599478-B1 Coating composition ROHM & HAAS (US) 1997-04-16 EP disclosed
US-5426129-A Curable ROHM AND HAAS COMPANY (US) 1995-06-20 US disclosed
US-5349026-A To form a tough film from aqueous dispersion of vinyl or arylic polymer ROHM AND HAAS COMPANY (US) 1994-09-20 US disclosed
EP-0599478-A1 Coating composition ROHM AND HAAS COMPANY (US) 1994-06-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230399288-A1 LACTATE/KETONE BODY ESTERS LDHB, LDHA, IL1B ALDH1A1 314/4885GABRP 1749/4885GABRD 3640/4885
US-20250304523-A1 COMBINED LACTATE AND KETONE BODY ESTERS FOR MEDICAL AND NUTRITIONAL USE LDHB, LDHA, LCT ALDH1A1 591/4885GABRP 1961/4885GABRD 3708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.