Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6574708 | 0.83 | KMT2A (0.65) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1876836 | 0.83 | KMT2A (0.65) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6576259 | 0.83 | KMT2A (0.65) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6574072 | 0.83 | KMT2A (0.65) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11780721 | 0.81 | LIPG (0.51) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL6574075 | 0.81 | DNM1 (0.64) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4188748 | 0.79 | MEN1 (0.47) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4193707 | 0.79 | SMN1; SMN2 (0.47) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Heptane SCHEMBL28938682 | 0.79 | LIPG (0.54) | ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL206091 | 0.79 | MEN1 (0.69) | DNM1MEN1KMT2ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764676-B1 | Method of preparing polycarbonate-polysiloxane block copolymers | GEN ELECTRIC (US) | 2004-04-28 | — | — | EP | claimed |
| EP-0764676-B1 | Method of preparing polycarbonate-polysiloxane block copolymers | GEN ELECTRIC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-5616674-A | USING PHASE TRANSFER CATALYSTS | GENERAL ELECTRIC COMPANY (US) | 1997-04-01 | — | — | US | disclosed |
| EP-0764676-A2 | Method of preparing polycarbonate-polysiloxane block copolymers | GENERAL ELECTRIC COMPANY (US) | 1997-03-26 | — | — | EP | disclosed |