Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Egtazic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.48 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | EYA2 | O00167 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831965 | 0.98 | BLM (0.80) | BLMPMP22HSD17B10TDP1EYA2 | |
| SCHEMBL2770982 | 0.96 | BLM (0.76) | BLMPMP22HSD17B10TDP1EYA2 | |
| SCHEMBL15508717 | 0.92 | BLM (0.69) | BLMPMP22HSD17B10TDP1EYA2 | |
| Ethylene Glycol SCHEMBL2860610 | 0.91 | BLM (0.68) | BLMPMP22HSD17B10TDP1EYA2 | |
| Ethylene Glycol SCHEMBL1742779 | 0.91 | BLM (0.68) | BLMPMP22HSD17B10TDP1EYA2 | |
| Hydrochloric Acid SCHEMBL15516229 | 0.90 | BLM (0.67) | BLMPMP22HSD17B10TDP1EYA2 | |
| SCHEMBL11684972 | 0.88 | BLM (1.00) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL920203 | 0.88 | BLM (1.00) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL22901 | 0.88 | BLM (1.00) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL23859106 | 0.86 | BLM (0.95) | BLMPMP22HSD17B10TDP1EYA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 240 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11672875-B2 | Nanoparticle-alginate gels for X-ray imaging of the vasculature | SAINT LOUIS UNIVERSITY (US) | 2023-06-13 | — | — | US | claimed |
| US-20230158160-A1 | PHARMACEUTICAL COMPOSITION OF EXTENDED-RELEASE ORAL SUSPENSION AND PROCESS FOR PREPARATION THEREOF | LYRUS LIFE SCIENCES PVT. LTD. (IN) | 2023-05-25 | — | — | US | claimed |
| EP-4153146-A1 | PHARMACEUTICAL COMPOSITION OF EXTENDED-RELEASE ORAL SUSPENSION AND PROCESS FOR PREPARATION THEREOF | Lyrus Life Sciences Pvt. LTD. (IN) | 2023-03-29 | — | — | EP | claimed |
| WO-2021240330-A1 | PHARMACEUTICAL COMPOSITION OF EXTENDED-RELEASE ORAL SUSPENSION AND PROCESS FOR PREPARATION THEREOF | LYRUS LIFE SCIENCES PVT LTD (IN) | 2021-12-02 | — | — | WO | claimed |
| US-9789196-B2 | Site-specific insulin-polymer conjugates | ANTRIABIO, INC. (US) | 2017-10-17 | — | — | US | claimed |
| US-20170100337-A1 | Naltrexone hydrochloride compositions | PURDUE PHARMA LP (US) | 2017-04-13 | — | — | US | claimed |
| EP-2599502-B1 | Method for preparation of site-specific protein conjugates | ANTRIABIO INC (US) | 2017-03-01 | — | — | EP | claimed |
| US-9492451-B2 | Stable compositions of tetrahydrobiopterin | DIPHARMA S.A. (CH) | 2016-11-15 | — | — | US | claimed |
| US-20150216995-A1 | Method for Preparation of Site-Specific Protein Conjugates | REZOLUTE, INC. | 2015-08-06 | — | — | US | claimed |
| US-9040664-B2 | Materials and methods for preparing protein-polymer conjugates | ANTRIABIO, INC. (US) | 2015-05-26 | — | — | US | claimed |
| US-20020146365-A1 | Method for the preparation of oxide powders | SAMSUNG CORNING CO., LTD. (KR) | 2002-10-10 | — | — | US | claimed |
| EP-0911039-A2 | Drug-resin complexes stabilized by chelating agents | Medeva Pharmaceutical Manufacturing, Inc. (US) | 1999-04-28 | — | — | EP | claimed |
| US-5106752-A | METHOD AND REAGENT FOR DETERMINING THE IONIC STRENGTH OR SPECIFIC GRAVITY OF AQUEOUS LIQUIDS | BOEHRINGER MANNHEIM GMBH (DE) | 1992-04-21 | — | — | US | claimed |
| US-5064615-A | Buffer, complex former, ph indicator, urine, test strips | BOEHRINGER MANNHEIM GMBH (DE) | 1991-11-12 | — | — | US | claimed |
| EP-0186188-B1 | LUBRICANT FOR WATER FITTINGS SUCH AS WATER TAPS AND THE LIKE | DOW CORNING GMBH (DE) | 1989-08-23 | — | — | EP | claimed |
| US-4784795-A | THICKENERS, ANTIDEPOSIT AGENTS | DOW CORNING GMBH (DE) | 1988-11-15 | — | — | US | claimed |
| US-4757098-A | Contains chelate agent stabilizer comprising for example ethylenediamine, nitrilotriacetic acid, ethylenediamine tetraacetic acid, 1,2-cyclohexylenediaminetetraacetic acid | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-07-12 | — | — | US | claimed |
| EP-0012184-B1 | HEMOLYTIC SOLUTION, APPLICATION OF SUCH A SOLUTION FOR DETERMINING THE PRESENCE OF GLUCOSE IN BLOOD, AND HEMOLYTIC PROCESS | MERCK PATENT GmbH (DE) | 1981-12-30 | — | — | EP | claimed |
| US-4297238-A | WHEREIN THE SOLUTION CONTAINS A BUFFER, SODIUM CHLORIDE, A SURFACTANT, AND A CHELATING AGENT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-10-27 | — | — | US | claimed |
| US-4212996-A | USING AN IRON OR ALUMINUM MASKING (COMPLEXING) AGENT CONTAINING AMINOACETIC ACID GROUPS | DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) | 1980-07-15 | — | — | US | claimed |