Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.64 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921496 | 0.92 | MTNR1B (0.72) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL9479608 | 0.89 | MTNR1B (0.68) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL2112594 | 0.89 | KMT2A (0.71) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL30741242 | 0.89 | KMT2A (0.71) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL9479511 | 0.89 | MTNR1B (0.68) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL30741237 | 0.89 | KMT2A (0.71) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL4544832 | 0.89 | KCNH3 (0.65) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL1085867 | 0.88 | MEN1 (0.71) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL1921418 | 0.87 | MTNR1B (0.66) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL30080139 | 0.86 | MTNR1B (0.65) | RAPGEF4MTNR1BMTNR1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108659050-B | Tetradentate ring metal platinum complex containing 6-substituted carbazole, preparation method and application | 浙江工业大学 | 2021-03-09 | — | — | CN | disclosed |
| US-10808197-B2 | Alkylated alkoxydiarylamine antioxidants | LANXESS SOLUTIONS US INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190322928-A1 | TETRADENTATE CYCLIC-METAL PLATINUM COMPLEXES COMPRISING 6-SUBSTITUTED CARBAZOLE, PRERATION AND USE THEREOF | ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) | 2019-10-24 | — | — | US | disclosed |
| US-20190322928-A1 | TETRADENTATE CYCLIC-METAL PLATINUM COMPLEXES COMPRISING 6-SUBSTITUTED CARBAZOLE, PRERATION AND USE THEREOF | ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) | 2019-10-24 | — | — | US | disclosed |
| US-20180079984-A1 | ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS | LANXESS CORPORATION | 2018-03-22 | — | — | US | disclosed |
| US-7541462-B2 | Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2009-06-02 | — | — | US | disclosed |
| US-7541462-B2 | Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2009-06-02 | — | — | US | disclosed |
| US-20080139806-A1 | TRIAMINOPHOSPHINE LIGANDS FOR CARBON-NITROGEN AND CARBON-CARBON BOND FORMATION | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.. | 2008-06-12 | — | — | US | disclosed |
| US-20080139806-A1 | TRIAMINOPHOSPHINE LIGANDS FOR CARBON-NITROGEN AND CARBON-CARBON BOND FORMATION | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.. | 2008-06-12 | — | — | US | disclosed |
| US-7385058-B1 | Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2008-06-10 | — | — | US | disclosed |
| US-7385058-B1 | Triaminophosphine ligands for carbon-nitrogen and carbon-carbon bond formation | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2008-06-10 | — | — | US | disclosed |
| EP-0937045-B1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | ALLERGAN INC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-5739338-A | SKIN DISORDERS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS, VISION DEFECTS, VIRICIDES, IMMUNOSUPPRESSANTS | ALLERGAN (US) | 1998-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10808197-B2 | Alkylated alkoxydiarylamine antioxidants | GPX4, CAT, SOD1 | RAPGEF4 3728/4885MTNR1B 477/4885MTNR1A 315/4885 |
| US-20080139806-A1 | TRIAMINOPHOSPHINE LIGANDS FOR CARBON-NITROGEN AND CARBON-CARBON BOND FORMATION | ABL1, AOC1, NPPA | RAPGEF4 1735/4885MTNR1B 2111/4885MTNR1A 3361/4885 |
| US-20180079984-A1 | ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS | GPX4, CAT, SOD1 | RAPGEF4 3728/4885MTNR1B 477/4885MTNR1A 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.