Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.32 |
| ▸ | AKT1 | P31749 | 4/20 | 0.32 |
| ▸ | MTOR | P42345 | 4/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28179885 | 0.97 | TSHR (0.48) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| SCHEMBL4620125 | 0.85 | TSHR (0.63) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| SCHEMBL5212 | 0.85 | — | — | |
| SCHEMBL28187979 | 0.84 | — | — | |
| SCHEMBL27945253 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL28062352 | 0.82 | LMNA (0.39) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| Hydrochloric Acid SCHEMBL443213 | 0.82 | — | — | |
| SCHEMBL17159759 | 0.82 | — | — | |
| SCHEMBL3136111 | 0.78 | TSHR (0.50) | TSHRLMNACYP3A4GABRA1GABRG2 | |
| SCHEMBL12212940 | 0.77 | TSHR (0.55) | TSHRLMNACYP3A4GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501236-B1 | N-[2-fluoro-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4-benzenesulfonamide derivatives as Raf protein kinase modulators for the treatment of cancer | PLEXXIKON INC (US) | 2017-03-29 | — | — | EP | claimed |
| EP-1247807-B1 | PROCESSES FOR PRODUCING TETRAHYDROPYRANYL-4-SULFONATE AND 4-AMINOTETRAHYDROPYRAN COMPOUND | UBE INDUSTRIES (JP) | 2004-04-28 | — | — | EP | claimed |
| US-6653489-B2 | Reacting 3-buten-1-ol with a formaldehyde compound and an organic sulfonic acid | UBE INDUSTRIES, INC. (JP) | 2003-11-25 | — | — | US | claimed |
| US-20030004359-A1 | Processes for producing tetrahydropyranyl-4-sulfonates and 4-aminotetrahydropyran compound | UBE INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | US | claimed |
| EP-1247807-A1 | PROCESSES FOR PRODUCING TETRAHYDROPYRANYL-4-SULFONATE AND 4-AMINOTETRAHYDROPYRAN COMPOUND | Ube Industries, Ltd. (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-3950692-A1 | NOVEL TRICYCLIC COMPOUNDS | AbbVie Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| US-20210061813-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBVIE INC. (US) | 2021-03-04 | — | — | US | disclosed |
| US-10793568-B2 | Hormone receptor modulators for treating metabolic conditions and disorders | ARDELYX, INC. (US) | 2020-10-06 | — | — | US | disclosed |
| US-20190233420-A1 | HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS | ARDELYX, INC. | 2019-08-01 | — | — | US | disclosed |
| US-RE47221-E1 | Tricyclic compounds | ABBVIE INC. (US) | 2019-02-05 | — | — | US | disclosed |
| CN-109053742-A | New tricyclic compound | ABBVIE 公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108774237-A | New tricyclic compound | ABBVIE 公司 | 2018-11-09 | — | — | CN | disclosed |
| US-20030004359-A1 | Processes for producing tetrahydropyranyl-4-sulfonates and 4-aminotetrahydropyran compound | UBE INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | US | disclosed |
| US-20030004359-A1 | Processes for producing tetrahydropyranyl-4-sulfonates and 4-aminotetrahydropyran compound | UBE INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | US | disclosed |
| US-20030004359-A1 | Processes for producing tetrahydropyranyl-4-sulfonates and 4-aminotetrahydropyran compound | UBE INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | US | disclosed |
| EP-1247807-A1 | PROCESSES FOR PRODUCING TETRAHYDROPYRANYL-4-SULFONATE AND 4-AMINOTETRAHYDROPYRAN COMPOUND | Ube Industries, Ltd. (JP) | 2002-10-09 | — | — | EP | disclosed |
| EP-1247807-A1 | PROCESSES FOR PRODUCING TETRAHYDROPYRANYL-4-SULFONATE AND 4-AMINOTETRAHYDROPYRAN COMPOUND | Ube Industries, Ltd. (JP) | 2002-10-09 | — | — | EP | disclosed |
| JP-2001226370-A | METHOD FOR PRODUCING 4-AMINOTETRAHYDROPYRANE DERIVATIVE | UBE IND LTD | 2001-08-21 | — | — | JP | disclosed |
| JP-2001163867-A | METHOD FOR PRODUCING TETRAHYDROPYRANYL-4-SULFONATE | UBE IND LTD | 2001-06-19 | — | — | JP | disclosed |
| WO-2001042232-A1 | PROCESSES FOR PRODUCING TETRAHYDROPYRANYL-4-SULFONATE AND 4-AMINOTETRAHYDROPYRAN COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2001-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004359-A1 | Processes for producing tetrahydropyranyl-4-sulfonates and 4-aminotetrahydropyran compound | HPD, DHPS, FDPS | TSHR 4244/4885LMNA 4733/4885CYP3A4 14/4885 |
| US-10793568-B2 | Hormone receptor modulators for treating metabolic conditions and disorders | NR1H4, FXR1, GLP1R | TSHR 19/4885LMNA 4360/4885CYP3A4 949/4885 |
| US-20210061813-A1 | NOVEL TRICYCLIC COMPOUNDS | CYP11B2, CYP11B1, ABCB1 | TSHR 3292/4885LMNA 2521/4885CYP3A4 11/4885 |
| US-20190233420-A1 | HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS | NR1H4, FXR1, GLP1R | TSHR 19/4885LMNA 4360/4885CYP3A4 949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.