Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 5/20 | 0.59 |
| ▸ | CASP3 | P42574 | 5/20 | 0.59 |
| ▸ | CTSK | P43235 | 7/20 | 0.55 |
| ▸ | CASP6 | P55212 | 4/20 | 0.49 |
| ▸ | CASP8 | Q14790 | 4/20 | 0.49 |
| ▸ | CASP7 | P55210 | 3/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.48 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | CAPNS1 | P04632 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583815 | 0.92 | CASP1 (0.62) | CASP1CASP3CTSKCASP6CASP8 | |
| SCHEMBL6577864 | 0.87 | CTSK (0.52) | CASP1CASP3CTSKCASP6CASP8 | |
| SCHEMBL6580257 | 0.86 | CTSK (0.55) | CASP1CASP3CTSKCAPN1CCR1 | |
| SCHEMBL6581051 | 0.85 | CASP1 (0.59) | CASP1CASP3CTSKCASP6CASP8 | |
| SCHEMBL5096684 | 0.83 | CTSK (0.51) | CASP1CASP3CTSKCAPN1CCR1 | |
| SCHEMBL5096679 | 0.83 | CTSK (0.51) | CASP1CASP3CTSKCAPN1CCR1 | |
| SCHEMBL6580161 | 0.83 | CTSK (0.66) | CASP1CASP3CTSK | |
| SCHEMBL6578205 | 0.81 | CASP1 (0.61) | CASP1CASP3CTSKCASP6CASP8 | |
| SCHEMBL6578192 | 0.81 | CTSK (0.65) | CASP1CASP3CTSK | |
| SCHEMBL6630009 | 0.80 | CTSK (0.55) | CTSKUTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180927-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2004-09-16 | — | — | US | claimed |
| EP-0936912-B1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORP (US) | 2004-02-11 | — | — | EP | claimed |
| US-20020128476-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2002-09-12 | — | — | US | claimed |
| US-20040180927-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2004-09-16 | — | — | US | disclosed |
| EP-0936912-B1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORP (US) | 2004-02-11 | — | — | EP | disclosed |
| US-20020128476-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2002-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180927-A1 | Inhibitors of cysteine protease | CTSK, CTSZ, CTSS | CASP1 131/4885CASP3 590/4885CTSK 1/4885 |
| US-20020128476-A1 | Inhibitors of cysteine protease | CTRC, RCE1, CTRL | CASP1 144/4885CASP3 171/4885CTSK 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.