Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.57 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | F3 | P13726 | 2/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916601 | 0.98 | MAPT (0.55) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL15120 | 0.83 | MAPT (0.61) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL376003 | 0.83 | MAPT (0.61) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL28287153 | 0.82 | MAPT (0.59) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Ammonia Solution, Strong SCHEMBL5175448 | 0.82 | MAPT (0.59) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL16268784 | 0.82 | MAPT (0.59) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Cinnamic Acid SCHEMBL361739 | 0.81 | MAPT (0.64) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Cinnamic Acid SCHEMBL361738 | 0.81 | MAPT (0.64) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL24119310 | 0.80 | GLA (0.64) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL7936575 | 0.80 | MAPT (0.57) | MAPTHDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980022-B1 | Method for preparing silver halide emulsion and silver halide photographic material | KONISHIROKU PHOTO IND (JP) | 2004-05-06 | — | — | EP | disclosed |
| US-6524782-B1 | No roller mark even during rapid processing at low replenish rates; no stain due to remained sensitizing dye; reacting silver salt and a halide salt in presence of fine silver halide grains containing gallium, indium and Group 8, 9, 10 | KONICA CORPORATION (JP) | 2003-02-25 | — | — | US | disclosed |
| EP-0980022-A1 | Method for preparing silver halide emulsion and silver halide photographic material | KONICA CORPORATION (JP) | 2000-02-16 | — | — | EP | disclosed |