Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 10/20 | 0.57 |
| ▸ | AKR1A1 | P14550 | 5/20 | 0.57 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | ILK | Q13418 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6575533 | 0.86 | AKR1B1 (0.55) | AKR1B1AKR1A1AKR1B10GLO1 | |
| SCHEMBL443712 | 0.73 | AKR1B1 (1.00) | AKR1B1AKR1A1 | |
| SCHEMBL17484182 | 0.71 | NPC1 (0.58) | AKR1B1AKR1A1ILKDYRK1AAKR1B10 | |
| SCHEMBL6575586 | 0.71 | GPR84 (0.58) | AKR1B1AKR1A1CDK4CCND1 | |
| SCHEMBL20964606 | 0.70 | DYRK1A (0.49) | AKR1B1AKR1A1ILKDYRK1AAKR1B10 | |
| SCHEMBL18383116 | 0.70 | HTR1D (0.69) | PCSK9HTR1DHTR2ACDK4CCND1 | |
| SCHEMBL6576362 | 0.70 | AKR1A1 (0.56) | AKR1B1AKR1A1PCSK9HTR1DHTR2A | |
| SCHEMBL20254213 | 0.69 | DYRK1A (0.50) | AKR1B1AKR1A1ILKDYRK1AAKR1B10 | |
| SCHEMBL5632209 | 0.69 | DYRK1A (0.50) | AKR1B1AKR1A1ILKDYRK1AAKR1B10 | |
| SCHEMBL31744779 | 0.68 | GPR84 (0.57) | AKR1B1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135124-B1 | ANTIHYPERTRIGLYCERIDEMIC, ANTIHYPERGLYCEMIC, ANTI-ANGIOGENIC AND WOUND HEALING SUBSTITUDED INDOLEALKANOIC ACIDS | INST FOR PHARM DISCOVERY INC (US) | 2004-04-28 | — | — | EP | disclosed |