Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5973964 | 0.85 | DGAT1 (0.40) | RAB9ANPC1SMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL28841366 | 0.82 | CNR2 (0.42) | RAB9ANPC1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11233228 | 0.81 | ALDH1A1 (0.43) | RAB9ANPC1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL13389039 | 0.73 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2OPRD1OPRM1 | |
| SCHEMBL7413642 | 0.73 | CTSL (0.40) | RAB9ANPC1SMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL11233121 | 0.72 | PPARG (0.45) | RAB9ANPC1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1593910 | 0.70 | SMN1; SMN2 (0.55) | RAB9ANPC1SMN1; SMN2OPRD1OPRM1 | |
| SCHEMBL5655500 | 0.69 | TLR8 (0.37) | RAB9ANPC1SMN1; SMN2 | |
| Ether SCHEMBL9242996 | 0.69 | MAPT (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3303697 | 0.69 | CTSL (0.43) | RAB9ANPC1SMN1; SMN2OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994876-B1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2004-09-08 | — | — | EP | disclosed |
| US-6380396-B1 | CHEMICAL INTERMEDIATES FOR ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |
| US-6207678-B1 | USED FOR TREATING INFLAMMATORY DISEASE SUCH AS ARTHRITIS, PSORIASIS, ASTHMA OR INFLAMMATORY BOWEL DISEASE, CENTRAL NERVOUS SYSTEM DISORDER SUCH AS ANXIETY, DEPRESSION, DEMENTIA OR PSYCHOSIS, GASTROINTESTINAL DISORDERS | PFIZER INC | 2001-03-27 | — | — | US | disclosed |
| EP-0994876-A1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | Pfizer Limited (GB) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057972-A1 | QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1998-12-23 | — | — | WO | disclosed |