Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 9/20 | 0.47 |
| ▸ | CASP1 | P29466 | 8/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 5/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 5/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 5/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.40 |
| ▸ | CTRL | P40313 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580107 | 0.85 | CTSK (0.69) | CTSKCTSLCASP3CASP1CTSB | |
| SCHEMBL6578107 | 0.85 | UTS2R (0.52) | CTSKCTSLCASP3CASP1CTSB | |
| SCHEMBL6577842 | 0.84 | CTSK (0.65) | CTSKCTSLCASP3CASP1CTSB | |
| SCHEMBL6582257 | 0.82 | CASP3 (0.53) | CTSKCTSLCASP3CASP1CASP6 | |
| SCHEMBL6580170 | 0.80 | CTSK (0.62) | CTSKCTSLCTSBUTS2R | |
| SCHEMBL6580235 | 0.79 | CASP3 (0.46) | CTSKCTSLCASP3CASP1CASP6 | |
| SCHEMBL6580234 | 0.79 | CTSL (0.49) | CTSKCTSLCASP3CASP1CTSB | |
| SCHEMBL6580295 | 0.77 | CTSK (0.60) | CTSKCTSLCTSB | |
| SCHEMBL6581038 | 0.77 | CTSK (0.73) | CTSKCTSLCTSB | |
| SCHEMBL6580271 | 0.77 | CTSK (0.66) | CTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180927-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2004-09-16 | — | — | US | claimed |
| EP-0936912-B1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORP (US) | 2004-02-11 | — | — | EP | claimed |
| US-20020128476-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2002-09-12 | — | — | US | claimed |
| US-20040180927-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2004-09-16 | — | — | US | disclosed |
| EP-0936912-B1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORP (US) | 2004-02-11 | — | — | EP | disclosed |
| US-20020128476-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2002-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180927-A1 | Inhibitors of cysteine protease | CTSK, CTSZ, CTSS | CTSK 1/4885CTSL 7/4885CASP3 590/4885 |
| US-20020128476-A1 | Inhibitors of cysteine protease | CTRC, RCE1, CTRL | CTSK 100/4885CTSL 8/4885CASP3 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.