Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 8/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL6583290 | 1.00 | HTR7 (0.43) | HTR7MEN1KMT2AHTR1AADRA1A | |
| Fumaric Acid SCHEMBL6581608 | 1.00 | HTR7 (0.43) | HTR7MEN1KMT2AHTR1AADRA1A | |
| SCHEMBL6217147 | 0.92 | MEN1 (0.46) | HTR7MEN1KMT2AHTR1AADRA1A | |
| SCHEMBL6217205 | 0.92 | MEN1 (0.46) | HTR7MEN1KMT2AHTR1AADRA1A | |
| SCHEMBL6219114 | 0.91 | MEN1 (0.47) | HTR7MEN1KMT2AHTR1AADRA1A | |
| SCHEMBL6216542 | 0.91 | MEN1 (0.47) | HTR7MEN1KMT2AHTR1AADRA1A | |
| Cadaverine Tartrate SCHEMBL6218477 | 0.88 | MEN1 (0.42) | HTR7MEN1KMT2AHTR1AADRA1A | |
| Cadaverine Tartrate SCHEMBL6217849 | 0.86 | MEN1 (0.43) | HTR7MEN1KMT2AHTR1AADRA1A | |
| SCHEMBL6581679 | 0.86 | SIGMAR1 (0.42) | HTR7MEN1KMT2AHTR1AADRA1A | |
| SCHEMBL6581687 | 0.86 | SIGMAR1 (0.42) | HTR7MEN1KMT2AHTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6835734-B2 | (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals, useful as intermediates for the preparation of levodropropizine | Dompé S.p.A. (IT) | 2004-12-28 | — | — | US | claimed |
| EP-1307441-B1 | 1,3-DIOXOLANES WITH ANTITUSSIVE ACTIVITY | DOMPE SPA (IT) | 2004-05-06 | — | — | EP | claimed |
| US-20040038989-A1 | 1,3-dioxolanes with antitussive activity | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2004-02-26 | — | — | US | claimed |
| EP-1307441-A1 | 1,3-DIOXOLANES WITH ANTITUSSIVE ACTIVITY | Dompe' S.P.A. (IT) | 2003-05-07 | — | — | EP | claimed |
| WO-2002010149-A1 | 1,3-DIOXOLANES WITH ANTITUSSIVE ACTIVITY | DOMPE' S.P.A. (IT) | 2002-02-07 | — | — | WO | claimed |
| US-6835734-B2 | (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals, useful as intermediates for the preparation of levodropropizine | Dompé S.p.A. (IT) | 2004-12-28 | — | — | US | disclosed |
| EP-1307441-B1 | 1,3-DIOXOLANES WITH ANTITUSSIVE ACTIVITY | DOMPE SPA (IT) | 2004-05-06 | — | — | EP | disclosed |
| US-20040038989-A1 | 1,3-dioxolanes with antitussive activity | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2004-02-26 | — | — | US | disclosed |
| EP-1307441-A1 | 1,3-DIOXOLANES WITH ANTITUSSIVE ACTIVITY | Dompe' S.P.A. (IT) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010149-A1 | 1,3-DIOXOLANES WITH ANTITUSSIVE ACTIVITY | DOMPE' S.P.A. (IT) | 2002-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038989-A1 | 1,3-dioxolanes with antitussive activity | ADRA1D, QDPR, PDE3A | MEN1 2068/4885KMT2A 4384/4885DRD2 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.