Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.55 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.55 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.54 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.53 |
| ▸ | CTSK | P43235 | 7/20 | 0.51 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CAPNS1 | P04632 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578205 | 0.90 | CASP1 (0.61) | UTS2RCAPN1CTSKCASP1CASP3 | |
| SCHEMBL6578118 | 0.88 | CTSK (0.51) | UTS2RCAPN1CTSKCASP1CASP3 | |
| SCHEMBL6577962 | 0.88 | CASP1 (0.54) | UTS2RCAPN1CTSKCASP1CASP3 | |
| SCHEMBL6578107 | 0.86 | UTS2R (0.52) | UTS2RCAPN1CTSKCASP1CASP3 | |
| SCHEMBL6578297 | 0.86 | CTSK (0.59) | GRNSORT1UTS2RCAPN1CTSK | |
| SCHEMBL6580537 | 0.85 | TAS1R3 (0.55) | UTS2RCAPN1CTSKCASP1CASP3 | |
| SCHEMBL6578370 | 0.84 | CTSK (0.55) | GRNSORT1UTS2RCTSKCTSB | |
| SCHEMBL6580571 | 0.84 | CTSK (0.49) | UTS2RCAPN1CTSKCASP1CASP3 | |
| SCHEMBL6581051 | 0.82 | CASP1 (0.59) | UTS2RCAPN1CTSKCASP1CASP3 | |
| SCHEMBL6580377 | 0.81 | UTS2R (0.54) | GRNSORT1UTS2RCAPN1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180927-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2004-09-16 | — | — | US | claimed |
| EP-0936912-B1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORP (US) | 2004-02-11 | — | — | EP | claimed |
| US-20020128476-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2002-09-12 | — | — | US | claimed |
| US-20040180927-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2004-09-16 | — | — | US | disclosed |
| EP-0936912-B1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORP (US) | 2004-02-11 | — | — | EP | disclosed |
| US-20020128476-A1 | Inhibitors of cysteine protease | SMITHKLINE BEECHAM CORPORATION | 2002-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180927-A1 | Inhibitors of cysteine protease | CTSK, CTSZ, CTSS | GRN 1681/4885SORT1 1537/4885UTS2R 1950/4885 |
| US-20020128476-A1 | Inhibitors of cysteine protease | CTRC, RCE1, CTRL | GRN 2813/4885SORT1 3985/4885UTS2R 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.