Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712343 | 0.79 | TDP1 (0.33) | TDP1NPC1RAB9ATTRALDH1A1 | |
| SCHEMBL9745800 | 0.74 | NR1H2 (0.32) | ALDH1A1 | |
| SCHEMBL31053112 | 0.73 | CA1 (0.31) | — | |
| SCHEMBL9746360 | 0.70 | TP53 (0.33) | MEN1KMT2AALDH1A1LMNAMAPK1 | |
| SCHEMBL4848439 | 0.70 | CA2 (0.34) | LMNA | |
| SCHEMBL4848522 | 0.70 | CA2 (0.34) | LMNA | |
| SCHEMBL926567 | 0.69 | CA2 (0.37) | — | |
| SCHEMBL2990802 | 0.69 | MAOB (0.56) | TDP1ALDH1A1ALOX12 | |
| (Chloromethyl)Benzene SCHEMBL4637240 | 0.69 | TP53 (0.50) | TDP1MAPTALDH1A1LMNA | |
| SCHEMBL31029241 | 0.67 | ALDH1A1 (0.42) | POLBESRRGTDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261613-B1 | GASTRO-SPECIFIC PRODRUGS | PHARMACIA CORP (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-1261613-A1 | GASTRO-SPECIFIC PRODRUGS | Pharmacia Corporation (US) | 2002-12-04 | — | — | EP | disclosed |
| US-6413945-B1 | REACTION PRODUCT OF ORGANOSILICON COMPOUNDS AND DRUG; ANTIULCER AGENTS | PHARMACIA CORPORATION | 2002-07-02 | — | — | US | disclosed |
| WO-2001064690-A1 | GASTRO-SPECIFIC PRODRUGS | PHARMACIA CORPORATION (US) | 2001-09-07 | — | — | WO | disclosed |
| US-6030959-A | FOR TREATMENT AND PROPHYLAXIS OF GASTRIC ULCERS | MONSANTO COMPANY (US) | 2000-02-29 | — | — | US | disclosed |