Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 3/20 | 0.31 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580976 | 0.79 | POLB (0.34) | TDP1TTRALDH1A1NPC1RAB9A | |
| SCHEMBL4848439 | 0.77 | CA2 (0.34) | TAAR1LMNA | |
| SCHEMBL4848522 | 0.77 | CA2 (0.34) | TAAR1LMNA | |
| SCHEMBL8908096 | 0.73 | ESR1 (0.33) | — | |
| SCHEMBL1313499 | 0.72 | ESR1 (0.35) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL22825991 | 0.72 | CA2 (0.34) | TAAR1LMNA | |
| SCHEMBL926567 | 0.72 | CA2 (0.37) | TAAR1 | |
| SCHEMBL10444591 | 0.72 | ESR1 (0.38) | ALDH1A1LMNA | |
| SCHEMBL2990802 | 0.71 | MAOB (0.56) | TDP1MAOAMAOBTAAR1ALDH1A1 | |
| SCHEMBL11848944 | 0.71 | CA1 (0.33) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827925-A | POLYMERIC MATERIAL BONDED TO DRUG THROUGH PH-SENSITIVE CLEAVABLE COVALENT BOND | MONSANTO COMPANY (US) | 1998-10-27 | — | — | US | disclosed |
| EP-0540580-B1 | POLYMERIC DRUG DELIVERY SYSTEM | SEARLE & CO (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0540580-A1 | POLYMERIC DRUG DELIVERY SYSTEM. | SEARLE & CO (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001477-A1 | POLYMERIC DRUG DELIVERY SYSTEM | G.D. SEARLE & CO. (US) | 1992-02-06 | — | — | WO | disclosed |