Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 2/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | CTSB | P07858 | 3/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | FPR2 | P25090 | 1/20 | 0.51 |
| ▸ | F13A1 | P00488 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | TGM1 | P22735 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27524304 | 0.90 | FPR2 (0.59) | CYP2C19SMN1; SMN2KMT2AMAPK1CAPN1 | |
| SCHEMBL6585220 | 0.90 | FPR2 (0.59) | CYP2C19SMN1; SMN2KMT2AMAPK1CAPN1 | |
| SCHEMBL6584160 | 0.88 | SMN1; SMN2 (0.57) | CYP2C19SMN1; SMN2TSHRMAPK1CTSK | |
| SCHEMBL11257249 | 0.87 | TACR1 (0.63) | TACR1P2RX7CTSKCTSBCTSL | |
| SCHEMBL11257246 | 0.87 | TACR1 (0.63) | TACR1P2RX7CTSKCTSBCTSL | |
| SCHEMBL8817272 | 0.85 | P2RX7 (0.57) | SMN1; SMN2KMT2ATACR1ACEP2RX7 | |
| SCHEMBL8817267 | 0.85 | P2RX7 (0.57) | SMN1; SMN2KMT2ATACR1ACEP2RX7 | |
| SCHEMBL8750811 | 0.85 | TACR1 (0.60) | TACR1ACEP2RX7CTSKCTSB | |
| SCHEMBL8750802 | 0.85 | TACR1 (0.60) | TACR1ACEP2RX7CTSKCTSB | |
| SCHEMBL2375169 | 0.84 | OPRK1 (0.53) | KMT2ATACR1ACEP2RX7CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815080-B1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA (IT) | 2004-06-16 | — | — | EP | disclosed |
| US-6002009-A | Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity | BOEHRINGER INGELHEIM ITALIA, S.P.A. (IT) | 1999-12-14 | — | — | US | disclosed |