Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 7/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122499 | 0.85 | KCNH2 (0.57) | KCNH2MGLLFAAHROCK2PIM1 | |
| SCHEMBL121755 | 0.83 | MGLL (0.56) | KCNH2MGLLFAAHROCK2PIM1 | |
| SCHEMBL149014 | 0.81 | KDM4E (0.54) | KCNH2MGLLEPHX2KDM4EALDH1A1 | |
| SCHEMBL6583340 | 0.81 | KCNH2 (0.53) | KCNH2MGLLFAAHROCK2PIM1 | |
| SCHEMBL28942962 | 0.77 | KCNH2 (0.49) | KCNH2MGLLFAAHROCK2PIM1 | |
| SCHEMBL30365056 | 0.77 | KCNH2 (0.49) | KCNH2MGLLFAAHROCK2PIM1 | |
| SCHEMBL20898076 | 0.76 | KDM4E (0.49) | KCNH2MGLLFAAHEPHX2KDM4E | |
| SCHEMBL3431894 | 0.75 | TUBB4A (0.52) | ALDH1A1HPGDSMN1; SMN2MAOB | |
| SCHEMBL5735272 | 0.73 | KCNH2 (0.60) | KCNH2MGLLFAAHEPHX2KDM4E | |
| SCHEMBL9463558 | 0.73 | KCNH2 (0.65) | KCNH2MGLLEPHX2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833376-B2 | 5-aminoalkyl and 5-aminocarbonyl substituted indole derivative useful for treatment of psychosis in a mammal | H. LUNDBECK A/S (DK) | 2004-12-21 | — | — | US | disclosed |
| EP-1214312-B1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2004-04-14 | — | — | EP | disclosed |
| US-20020169169-A1 | 5-aminoalkyl and 5-aminocarbonyl substituted indoles | H. LUNDBECK A/S (DK) | 2002-11-14 | — | — | US | disclosed |
| EP-1214312-A1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001021614-A1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2001-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169169-A1 | 5-aminoalkyl and 5-aminocarbonyl substituted indoles | ADRB1, ADRA2C, ADRB2 | KCNH2 79/4885MGLL 2216/4885FAAH 759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.