Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.72 |
| ▸ | HTR1B | P28222 | 7/20 | 0.72 |
| ▸ | DRD2 | P14416 | 4/20 | 0.72 |
| ▸ | HTR2C | P28335 | 4/20 | 0.72 |
| ▸ | HRH1 | P35367 | 4/20 | 0.72 |
| ▸ | DRD4 | P21917 | 4/20 | 0.72 |
| ▸ | DRD3 | P35462 | 4/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.72 |
| ▸ | MLNR | O43193 | 1/20 | 0.72 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.72 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581962 | 0.89 | DRD2 (0.73) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL1135593 | 0.87 | HTR1A (0.86) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL8642590 | 0.86 | HTR1A (0.80) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL8642980 | 0.86 | HTR1A (0.80) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL6578793 | 0.85 | DRD2 (0.80) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| Sertindole SCHEMBL112092 | 0.84 | KCNH2 (1.00) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL8640337 | 0.84 | HTR1A (0.80) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| Sertindole SCHEMBL29360085 | 0.84 | KCNH2 (1.00) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL8636278 | 0.83 | HTR1A (0.77) | HTR1AHTR1BDRD2HTR2CHRH1 | |
| SCHEMBL8640470 | 0.83 | HTR1A (0.79) | HTR1AHTR1BDRD2HTR2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214312-B1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2004-04-14 | — | — | EP | claimed |
| US-20020169169-A1 | 5-aminoalkyl and 5-aminocarbonyl substituted indoles | H. LUNDBECK A/S (DK) | 2002-11-14 | — | — | US | claimed |
| EP-1214312-A1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2002-06-19 | — | — | EP | claimed |
| WO-2001021614-A1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2001-03-29 | — | — | WO | claimed |
| US-6833376-B2 | 5-aminoalkyl and 5-aminocarbonyl substituted indole derivative useful for treatment of psychosis in a mammal | H. LUNDBECK A/S (DK) | 2004-12-21 | — | — | US | disclosed |
| EP-1214312-B1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2004-04-14 | — | — | EP | disclosed |
| US-20020169169-A1 | 5-aminoalkyl and 5-aminocarbonyl substituted indoles | H. LUNDBECK A/S (DK) | 2002-11-14 | — | — | US | disclosed |
| EP-1214312-A1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001021614-A1 | 5-AMINOALKYL AND 5-AMINOCARBONYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 2001-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169169-A1 | 5-aminoalkyl and 5-aminocarbonyl substituted indoles | ADRB1, ADRA2C, ADRB2 | HTR1A 77/4885HTR1B 56/4885DRD2 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.