Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24201 | 0.84 | LMNA (0.60) | LMNAGAAALDH1A1ALOX15PPIA | |
| SCHEMBL344491 | 0.83 | ALDH1A1 (0.56) | LMNAGAAALDH1A1ALOX15HPGD | |
| SCHEMBL11009342 | 0.83 | ALDH1A1 (0.42) | LMNAGAAALDH1A1ALOX15HPGD | |
| SCHEMBL29688494 | 0.82 | ALDH1A1 (0.58) | LMNAGAAALDH1A1ALOX15HPGD | |
| SCHEMBL993303 | 0.82 | ALDH1A1 (0.58) | LMNAGAAALDH1A1ALOX15HPGD | |
| SCHEMBL5143960 | 0.81 | PARP1 (0.56) | LMNAGAAALDH1A1HPGDPARP1 | |
| SCHEMBL30608075 | 0.81 | PARP1 (0.56) | LMNAGAAALDH1A1HPGDPARP1 | |
| SCHEMBL10907542 | 0.77 | LMNA (0.41) | LMNAGAAALDH1A1HPGDPARP1 | |
| SCHEMBL197671 | 0.77 | HSD11B1 (0.56) | ALDH1A1ALOX15HPGDHSD11B1 | |
| Benzoyl Chloride SCHEMBL8103514 | 0.76 | LMNA (0.51) | LMNAGAAALDH1A1ALOX15CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379515-A1 | LIPID LOWERING BIPHENYLCARBOXAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-01-14 | — | — | EP | disclosed |
| EP-1326835-A1 | BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-1317431-A2 | POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002081460-A1 | LIPID LOWERING BIPHENYLCARBOXAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-10-17 | — | — | WO | disclosed |
| WO-2002028835-A1 | BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-11 | — | — | WO | disclosed |
| WO-2002020501-A2 | POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-14 | — | — | WO | disclosed |
| EP-0887345-A1 | 4'-trifluoromethylbiphenyl-2-carboxylic acid-[2-(2-acetylaminoethyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]amide hydrochloride as apo B-secretion/MTP inhibitors | PFIZER INC. (US) | 1998-12-30 | — | — | EP | disclosed |