Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 10/20 | 0.45 |
| ▸ | HTR1A | P08908 | 8/20 | 0.45 |
| ▸ | HTR2A | P28223 | 7/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310251 | 0.97 | DRD2 (0.46) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6584872 | 0.97 | DRD2 (0.48) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL8308890 | 0.95 | DRD2 (0.49) | MAOAMAOBDRD2HTR1AHTR2A | |
| Oxalic Acid SCHEMBL7508229 | 0.84 | MEN1 (0.47) | MAOAMAOBDRD2HTR1AHTR7 | |
| SCHEMBL6586848 | 0.83 | HTR1A (0.42) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6585521 | 0.83 | HTR1A (0.42) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6589109 | 0.82 | DRD2 (0.62) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6581869 | 0.82 | HTR1A (0.43) | DRD2HTR1AHTR7MEN1MAPT | |
| SCHEMBL6584980 | 0.82 | DRD2 (0.45) | DRD2HTR1AHTR7MEN1MAPT | |
| SCHEMBL6583485 | 0.81 | MAOA (0.70) | MAOAMAOBDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |