Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 1/20 | 0.55 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.53 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373015 | 0.86 | MCL1 (0.55) | ENPP3ENPP1MCL1XDHPRMT5 | |
| SCHEMBL25068057 | 0.79 | KDM4E (0.58) | MEN1POLBRAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL602093 | 0.79 | KDM4E (0.61) | MEN1POLBRAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL7379345 | 0.79 | PRMT5 (0.59) | ENPP3ENPP1MCL1XDHPRMT5 | |
| SCHEMBL6587722 | 0.78 | LMNA (0.63) | ENPP3ENPP1MCL1XDHPRMT5 | |
| SCHEMBL7528767 | 0.77 | PRMT5 (0.55) | ENPP3ENPP1MCL1XDHPRMT5 | |
| SCHEMBL603696 | 0.77 | NUDT1 (0.48) | MCL1PRMT5SMN1; SMN2ALOX5ALDH1A1 | |
| SCHEMBL9013572 | 0.76 | KDM4E (0.53) | ENPP3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL8614763 | 0.74 | RAB9A (0.54) | ENPP3ENPP1MCL1XDHPRMT5 | |
| SCHEMBL8615437 | 0.74 | RAB9A (0.57) | ENPP3ENPP1MCL1XDHPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781766-B1 | HETEROCYCLIC DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO LTD (JP) | 2004-03-31 | — | — | EP | disclosed |
| CN-1118454-C | Heterocyclic derivative and medicine | NIPPON SHINYAKU CO LTD (JP) | 2003-08-20 | — | — | CN | disclosed |
| US-6191149-B1 | DRUG FOR CEREBROVASCULAR DISEASE | NIPPON SHINYAKU, CO., LTD. (JP) | 2001-02-20 | — | — | US | disclosed |
| US-5945426-A | PREVENT NEURONAL DEATH | NIPPON SHINYAKU CO., LTD. (JP) | 1999-08-31 | — | — | US | disclosed |
| CN-1157609-A | Heterocyclic derivative and medicine | NIPPON SHINYAKU CO LTD (JP) | 1997-08-20 | — | — | CN | disclosed |
| EP-0781766-A1 | HETEROCYCLIC DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1997-07-02 | — | — | EP | disclosed |