Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.53 |
| ▸ | DHFR | P00374 | 2/20 | 0.51 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.49 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379345 | 0.90 | PRMT5 (0.59) | LMNAPRMT5DHFRENPP3ENPP1 | |
| SCHEMBL14311057 | 0.80 | ALOX5 (0.49) | LMNAPRMT5MEN1POLBRAB9A | |
| SCHEMBL1772953 | 0.79 | LMNA (1.00) | LMNAMEN1POLBRAB9AKMT2A | |
| SCHEMBL6587114 | 0.78 | ENPP3 (0.55) | PRMT5ENPP3ENPP1GSTP1MEN1 | |
| SCHEMBL8665281 | 0.77 | ALDH1A1 (0.49) | LMNAPRMT5ALOX5 | |
| SCHEMBL9424186 | 0.77 | DHFR (0.50) | LMNAPRMT5DHFRENPP3ENPP1 | |
| SCHEMBL632828 | 0.76 | LMNA (0.64) | LMNAMEN1RAB9AKMT2ANPSR1 | |
| SCHEMBL7379441 | 0.76 | LMNA (0.59) | LMNADHFRENPP3ENPP1GSTP1 | |
| SCHEMBL7373015 | 0.75 | MCL1 (0.55) | LMNAPRMT5ENPP3ENPP1GSTP1 | |
| SCHEMBL17094749 | 0.75 | DHFR (0.48) | LMNAPRMT5DHFRENPP3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781766-B1 | HETEROCYCLIC DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO LTD (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-6191149-B1 | DRUG FOR CEREBROVASCULAR DISEASE | NIPPON SHINYAKU, CO., LTD. (JP) | 2001-02-20 | — | — | US | disclosed |
| US-5945426-A | PREVENT NEURONAL DEATH | NIPPON SHINYAKU CO., LTD. (JP) | 1999-08-31 | — | — | US | disclosed |
| EP-0781766-A1 | HETEROCYCLIC DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1997-07-02 | — | — | EP | disclosed |