SCHEMBL6592333

SCHEMBL6592333

Cc1ccc(C)c(COc2ccc3oc(-c4oc(=O)c(C)c(O)c4C)cc3c2)c1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ACHE P22303 4/20 0.43
MAOB P27338 12/20 0.39
SLC26A4 O43511 1/20 0.38
ABL1 P00519 1/20 0.36
SRC P12931 1/20 0.36
TP53 P04637 1/20 0.36
MAPT P10636 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6594915 0.93 ACHE (0.41) ACHEMAOBSLC26A4TP53MAPT
SCHEMBL6594002 0.92 ACHE (0.45) ACHEMAOB
SCHEMBL6591035 0.85 MAOB (0.44) ACHEMAOB
SCHEMBL6592681 0.85 ACHE (0.43) ACHEMAOBMAPT
SCHEMBL6593754 0.85 ACHE (0.43) ACHEMAOB
SCHEMBL6597833 0.83 MAOB (0.48) ACHEMAOBSLC26A4
SCHEMBL6593972 0.83 ACHE (0.44) ACHEMAOBSLC26A4
SCHEMBL6594556 0.83 SLC26A4 (0.51) ACHEMAOBSLC26A4
SCHEMBL6591398 0.82 MAOB (0.54) ACHEMAOB
SCHEMBL6592595 0.82 SLC26A4 (0.43) ACHEMAOBSLC26A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1063235-B1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LTD (JP) 2004-05-12 EP disclosed
US-20030186976-A1 Benzofurylpyrone derivatives TEIJIN LIMITED, MICROBIAL CHEMISTRY RESEARCH FOUNDATION 2003-10-02 US disclosed
US-6589984-B1 Blood cholesterol and triglycerides (TG) themselves are generally insoluble in blood, and they exist as lipoproteins by binding with apolipoproteins. In the body, triglycerides are biosynthesized primarily in the liver from acetyl CoA as TEIJIN LIMITED (JP) 2003-07-08 US disclosed
EP-1063235-A1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LIMITED (JP) 2000-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030186976-A1 Benzofurylpyrone derivatives PLIN5, ACSL5, PLIN1 ACHE 4708/4885MAOB 3367/4885SLC26A4 4640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.