Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.84 |
| ▸ | TSHR | P16473 | 2/20 | 0.84 |
| ▸ | POLB | P06746 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.84 |
| ▸ | PARP1 | P09874 | 1/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | RECQL | P46063 | 1/20 | 0.84 |
| ▸ | BLM | P54132 | 1/20 | 0.84 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.84 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.84 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.62 |
| ▸ | DHODH | Q02127 | 2/20 | 0.61 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.56 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.56 |
| ▸ | KMO | O15229 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL5070344 | 0.95 | MAPT (0.76) | MAPTTSHRPOLBCYP3A4PARP1 | |
| SCHEMBL153199 | 0.92 | MKNK1 (0.71) | MAPTTSHRPOLBCYP3A4PARP1 | |
| SCHEMBL27626919 | 0.92 | MKNK1 (0.71) | MAPTTSHRPOLBCYP3A4PARP1 | |
| Benzamide SCHEMBL1332331 | 0.92 | — | — | |
| Benzamide SCHEMBL30112947 | 0.92 | PARP1 (1.00) | MAPTTSHRPOLBCYP3A4PARP1 | |
| Benzamide SCHEMBL29618402 | 0.92 | — | — | |
| Benzamide SCHEMBL16352 | 0.92 | — | — | |
| Benzamide SCHEMBL6690447 | 0.92 | PARP1 (1.00) | MAPTTSHRPOLBCYP3A4PARP1 | |
| SCHEMBL21755166 | 0.92 | PARP1 (1.00) | MAPTTSHRPOLBCYP3A4PARP1 | |
| Benzamide SCHEMBL1222101 | 0.92 | PARP1 (1.00) | MAPTTSHRPOLBCYP3A4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480516-B1 | MICROBICIDAL AGENTS ON THE BASIS OF BIPHENYL BENZAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2010-02-03 | — | — | EP | claimed |
| US-7186862-B2 | Microbicidal agents on the basis of biphenylbenzamide derivatives | BAYER CROPSCIENCE AG (DE) | 2007-03-06 | — | — | US | claimed |
| US-20050119347-A1 | Microbicidal agents on the basis of biphenyl benzamide derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2005-06-02 | — | — | US | claimed |
| CN-103980152-B | Benzamide compounds with anti-tumor activity and its preparation method and application | XI'AN JIAOTONG UNIVERSITY (CN) | 2016-04-27 | — | — | CN | disclosed |
| US-9187523-B2 | Substrate peptide sequences for plague plasminogen activator and uses thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-11-17 | — | — | US | disclosed |
| EP-1896395-B1 | MODIFIED MALONATE DERIVATIVES | MERCK SHARP & DOHME (US) | 2015-07-15 | — | — | EP | disclosed |
| CN-103980152-A | Benzamide compound with antitumor activity as well as preparation method and application thereof | UNIV XI AN JIAOTONG | 2014-08-13 | — | — | CN | disclosed |
| US-20130131041-A1 | SPIROCYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | US | disclosed |
| US-8349825-B2 | Spirocyclic compounds | MERCK SHARP & DOHME CORP. (US) | 2013-01-08 | — | — | US | disclosed |
| US-8158825-B2 | Modified malonate derivatives | MERCK SHARP & DOHME CORP. (US) | 2012-04-17 | — | — | US | disclosed |
| US-20120045474-A1 | Substrate peptide sequences for plague plasminogen activator and uses thereof | MOTIN VLADIMIR L (US) | 2012-02-23 | — | — | US | disclosed |
| US-6258843-B1 | DRUGS AS ENZYME INHIBITORS | NOVARTIS AG (CH) | 2001-07-10 | — | — | US | disclosed |
| US-6090817-A | Phenylpyridine derivatives useful as phosphodiesterase inhibitors | NOVARTIS AG (CH) | 2000-07-18 | — | — | US | disclosed |
| US-6090817-A | Phenylpyridine derivatives useful as phosphodiesterase inhibitors | NOVARTIS AG (CH) | 2000-07-18 | — | — | US | disclosed |
| CN-1216980-A | Triaryl compounds | NOVARTIS AG (CH) | 1999-05-19 | — | — | CN | disclosed |
| CN-1216980-A | Triaryl compounds | NOVARTIS AG (CH) | 1999-05-19 | — | — | CN | disclosed |
| EP-0885193-A1 | TRIARYL COMPOUNDS | Novartis AG (CH) | 1998-12-23 | — | — | EP | disclosed |
| EP-0885193-A1 | TRIARYL COMPOUNDS | Novartis AG (CH) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032853-A1 | TRIARYL COMPOUNDS | NOVARTIS AG (CH) | 1997-09-12 | — | — | WO | disclosed |
| WO-1997032853-A1 | TRIARYL COMPOUNDS | NOVARTIS AG (CH) | 1997-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119347-A1 | Microbicidal agents on the basis of biphenyl benzamide derivatives | DDT, MSR1, CYP1B1 | MAPT 4798/4885TSHR 1824/4885POLB 1478/4885 |
| US-20130131041-A1 | SPIROCYCLIC COMPOUNDS | BRDT, TXNRD3, HDAC1 | MAPT 1986/4885TSHR 635/4885POLB 4013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.