Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.53 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.53 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.53 |
| ▸ | F7 | P08709 | 1/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.52 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084771 | 0.83 | ALDH1A1 (0.57) | ALDH1A1PLOD2KMT2ALMNAMEN1 | |
| SCHEMBL82139 | 0.81 | PLOD2 (0.67) | ALDH1A1PLOD2KMT2AMEN1MAPT | |
| SCHEMBL30489909 | 0.81 | PLOD2 (0.67) | ALDH1A1PLOD2KMT2AMEN1MAPT | |
| SCHEMBL905439 | 0.79 | PLOD2 (0.65) | ALDH1A1PLOD2KMT2ALMNAAPP | |
| SCHEMBL29626189 | 0.79 | PLOD2 (0.65) | ALDH1A1PLOD2KMT2ALMNAAPP | |
| Hydrochloric Acid SCHEMBL6946997 | 0.79 | PLOD2 (0.65) | ALDH1A1PLOD2KMT2AMEN1MAPT | |
| SCHEMBL6921708 | 0.79 | LMNA (0.55) | ALDH1A1PLOD2KMT2ALMNAMEN1 | |
| SCHEMBL7075878 | 0.79 | PLOD2 (0.69) | ALDH1A1PLOD2KMT2ALMNAAPP | |
| SCHEMBL10320930 | 0.79 | PLOD2 (0.89) | ALDH1A1PLOD2KMT2ALMNAMEN1 | |
| SCHEMBL29554726 | 0.79 | PLOD2 (0.89) | ALDH1A1PLOD2KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11230524-B2 | Myocyte enhancer factor 2 (MEF2) modulators | STANDARD LLC (US) | 2022-01-25 | — | — | US | disclosed |
| US-20190241504-A1 | Novel Myocyte Enhancer Factor 2 (MEF2) modulators | STANDARD LLC | 2019-08-08 | — | — | US | disclosed |
| US-10010536-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20170095462-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE, INC. | 2017-04-06 | — | — | US | disclosed |
| US-9527816-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2016-12-27 | — | — | US | disclosed |
| EP-2591784-B1 | Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system | INTERMUNE INC (US) | 2016-09-14 | — | — | EP | disclosed |
| EP-1928454-B1 | PYRIDONE DERIVATIVES FOR MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE INC (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20140228310-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE, INC. (US) | 2014-08-14 | — | — | US | disclosed |
| US-8741936-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2014-06-03 | — | — | US | disclosed |
| EP-2591784-A1 | Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system | Intermune, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| US-20120046321-A1 | METHODS OF TREATING ATRIAL FIBRILLATION WITH P38 INHIBITOR COMPOUNDS | INTERMUNE, INC. (US) | 2012-02-23 | — | — | US | disclosed |
| US-20100240704-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE, INC. | 2010-09-23 | — | — | US | disclosed |
| US-7728013-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-20100029578-A1 | Methods of Treating Atrial Fibrillation with P38 Inhibitor Compounds | INTERMUNE, INC. | 2010-02-04 | — | — | US | disclosed |
| EP-1948178-A2 | METHODS OF TREATING ATRIAL FIBRILLATION WITH P38 INHIBITOR COMPOUNDS | Intermune, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| EP-1928454-A2 | PYRIDONE DERIVATIVES FOR MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | Intermune, Inc. (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007053685-A2 | METHODS OF TREATING ATRIAL FIBRILLATION WITH P38 INHIBITOR COMPOUNDS | INTERMUNE, INC. (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20060270612-A1 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. | 2006-11-30 | — | — | US | disclosed |
| WO-2006122154-A2 | PYRIDONE DERIVATIVES FOR MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| EP-0244728-A2 | Use of heteroarylethyl amines to stimulate animal growth, heteroarylethyl amines and process for their preparation | BAYER AG (DE) | 1987-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230524-B2 | Myocyte enhancer factor 2 (MEF2) modulators | MEF2D, MYLK2, TNNT2 | ALDH1A1 4009/4885PLOD2 2948/4885KMT2A 1408/4885 |
| US-20100240704-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | MAPKAPK2, MAP3K6, MAP4K1 | ALDH1A1 3375/4885PLOD2 4570/4885KMT2A 4406/4885 |
| US-20100029578-A1 | Methods of Treating Atrial Fibrillation with P38 Inhibitor Compounds | ATF1, MAPKAPK3, MAPKAPK2 | ALDH1A1 900/4885PLOD2 4430/4885KMT2A 3709/4885 |
| US-10010536-B2 | Method of modulating stress-activated protein kinase system | MAPKAPK2, MAP3K6, MAP4K1 | ALDH1A1 3375/4885PLOD2 4570/4885KMT2A 4406/4885 |
| US-20120046321-A1 | METHODS OF TREATING ATRIAL FIBRILLATION WITH P38 INHIBITOR COMPOUNDS | ATF1, MAPKAPK3, MAPKAPK2 | ALDH1A1 900/4885PLOD2 4430/4885KMT2A 3709/4885 |
| US-20170095462-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | MAPKAPK2, MAP3K6, MAP4K1 | ALDH1A1 3375/4885PLOD2 4570/4885KMT2A 4406/4885 |
| US-20190241504-A1 | Novel Myocyte Enhancer Factor 2 (MEF2) modulators | MEF2D, MYLK2, MYOF | ALDH1A1 4281/4885PLOD2 1506/4885KMT2A 1527/4885 |
| US-20140228310-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | MAPKAPK2, MAP3K6, MAP4K1 | ALDH1A1 3375/4885PLOD2 4570/4885KMT2A 4406/4885 |
| US-20060270612-A1 | Method of modulating stress-activated protein kinase system | MAPKAPK2, MAP3K6, MAP4K1 | ALDH1A1 3375/4885PLOD2 4570/4885KMT2A 4406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.