SCHEMBL6596747

SCHEMBL6596747

Cc1c(-c2cc3cc(CCNCCc4ccccc4O)ccc3o2)oc(=O)c(C)c1O

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 3/20 0.38
MAOB P27338 3/20 0.37
MPO P05164 5/20 0.36
MEN1 O00255 1/20 0.35
LMNA P02545 1/20 0.35
MAPK1 P28482 1/20 0.35
KMT2A Q03164 1/20 0.35
AKR1B10 O60218 1/20 0.35
AKR1B1 P15121 1/20 0.35
MAOA P21397 1/20 0.34
PTGES O14684 1/20 0.34
ALOX5 P09917 1/20 0.34
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA9 Q16790 2/20 0.34
CNR2 P34972 3/20 0.33
GPR55 Q9Y2T6 2/20 0.33
CNR1 P21554 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6593044 0.95 AKR1B10 (0.37) FFAR1MAOBMPOMEN1LMNA
SCHEMBL6590495 0.86 MAOB (0.41) MAOBMAOACA12CA9
SCHEMBL6596741 0.79 FFAR1 (0.41) FFAR1MAOBMEN1KMT2AMAOA
SCHEMBL6591956 0.79 ADRB1 (0.46)
SCHEMBL6593040 0.76 SIGMAR1 (0.42) FFAR1PTGESALOX5
SCHEMBL27559006 0.76 FFAR1 (0.41) FFAR1PTGESALOX5
SCHEMBL6592355 0.76 NPC1 (0.47) MEN1LMNAKMT2A
SCHEMBL28747065 0.75 FFAR1 (0.40) FFAR1PTGESALOX5
SCHEMBL6592910 0.74 ADRB1 (0.44)
SCHEMBL6597257 0.74 KDM4E (0.50) MAOBMEN1LMNAKMT2AAKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1063235-B1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LTD (JP) 2004-05-12 EP disclosed
US-20030186976-A1 Benzofurylpyrone derivatives TEIJIN LIMITED, MICROBIAL CHEMISTRY RESEARCH FOUNDATION 2003-10-02 US disclosed
US-6589984-B1 Blood cholesterol and triglycerides (TG) themselves are generally insoluble in blood, and they exist as lipoproteins by binding with apolipoproteins. In the body, triglycerides are biosynthesized primarily in the liver from acetyl CoA as TEIJIN LIMITED (JP) 2003-07-08 US disclosed
EP-1063235-A1 BENZOFURYLPYRONE DERIVATIVES TEIJIN LIMITED (JP) 2000-12-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030186976-A1 Benzofurylpyrone derivatives PLIN5, ACSL5, PLIN1 FFAR1 66/4885MAOB 3367/4885MPO 3143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.