Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27524304 | 0.81 | FPR2 (0.59) | GAACYP2C19SMN1; SMN2CAPN1ALDH1A1 | |
| SCHEMBL6585220 | 0.81 | FPR2 (0.59) | GAACYP2C19SMN1; SMN2CAPN1ALDH1A1 | |
| SCHEMBL6588325 | 0.77 | CTRB1 (0.57) | — | |
| SCHEMBL5362231 | 0.75 | GRIN2D (0.57) | GAACYP2C19SMN1; SMN2LTA4HNPC1 | |
| SCHEMBL18065507 | 0.75 | MMEL1 (0.54) | SMN1; SMN2LTA4HALDH1A1MEN1KMT2A | |
| SCHEMBL16692005 | 0.75 | MMEL1 (0.54) | SMN1; SMN2LTA4HALDH1A1MEN1KMT2A | |
| SCHEMBL7569039 | 0.75 | CTRB1 (0.49) | CYP2C19SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL7569030 | 0.75 | CTRB1 (0.49) | CYP2C19SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL7569034 | 0.75 | CTRB1 (0.49) | CYP2C19SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL7361852 | 0.75 | CTRB1 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815080-B1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA (IT) | 2004-06-16 | — | — | EP | disclosed |
| US-6002009-A | Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity | BOEHRINGER INGELHEIM ITALIA, S.P.A. (IT) | 1999-12-14 | — | — | US | disclosed |
| EP-0815080-A1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT 4? ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028424-A1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-09-19 | — | — | WO | disclosed |