Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600284 | 0.78 | LMNA (0.45) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL2943501 | 0.71 | LTB4R (0.62) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL28305301 | 0.70 | LTB4R (0.61) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL15515881 | 0.70 | LTB4R (0.47) | ALDH1A1SMN1; SMN2KMT2AGAAHTT | |
| SCHEMBL6820910 | 0.69 | LTB4R (0.44) | ALDH1A1KMT2APOLBGAAHTT | |
| SCHEMBL28647090 | 0.68 | LTB4R (0.49) | ALDH1A1SMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL11121501 | 0.66 | LTB4R (0.51) | ALDH1A1SMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL10858310 | 0.65 | PIN1 (0.62) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL10858317 | 0.65 | PIN1 (0.62) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL6552425 | 0.65 | LTB4R (0.57) | ALDH1A1KMT2AGAAHTTLTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003076435-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | disclosed |