SCHEMBL6601880

SCHEMBL6601880

CCOC(=O)CCCCCNC(=O)Nc1cccc(-n2nc(OC)oc2=O)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.54
EPHX2 P34913 3/20 0.47
MGLL Q99685 3/20 0.45
FAAH O00519 1/20 0.45
LMNA P02545 1/20 0.44
ABHD16A O95870 1/20 0.43
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
EPHX1 P07099 3/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6602792 0.89 ALDH1A1 (0.55) ALDH1A1EPHX2MGLLFAAHLMNA
SCHEMBL7657538 0.76 MGLL (0.59) ALDH1A1MGLLFAAHLMNAABHD16A
Trifluoroacetic Acid SCHEMBL6601602 0.74 MGLL (0.50) MGLLFAAHABHD16A
Trifluoroacetic Acid SCHEMBL6601176 0.74 MGLL (0.50) MGLLFAAHABHD16A
SCHEMBL15741881 0.73 ALDH1A1 (0.97) ALDH1A1EPHX2LMNAHDAC3HDAC4
SCHEMBL6683243 0.71 HDAC3 (0.79) ALDH1A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL15750288 0.71 ALDH1A1 (0.73) ALDH1A1EPHX2LMNAHDAC3HDAC4
SCHEMBL6682243 0.70 HDAC3 (0.74) ALDH1A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL6601946 0.70 LPL (0.57) ALDH1A1MGLLFAAHABHD16AHDAC3
SCHEMBL6682108 0.69 HDAC3 (0.76) ALDH1A1EPHX2HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1263745-B1 SUBSTITUTED 3-PHENYL-5-ALKOXI-1,3,4-OXDIAZOL-2-ONE AND USE THEREOF FOR INHIBITING HORMONE-SENSITIVE LIPASE AVENTIS PHARMA GMBH (DE) 2004-05-19 EP disclosed