Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 2/20 | 0.48 |
| ▸ | F13A1 | P00488 | 1/20 | 0.48 |
| ▸ | TGM1 | P22735 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260332 | 1.00 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 | |
| SCHEMBL8393648 | 0.90 | LMNA (0.58) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 | |
| SCHEMBL30732657 | 0.88 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 | |
| SCHEMBL11568337 | 0.88 | PREP (0.53) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 | |
| SCHEMBL29652185 | 0.85 | LMNA (0.52) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 | |
| SCHEMBL14451403 | 0.85 | LMNA (0.52) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 | |
| SCHEMBL8029231 | 0.85 | ALDH1A1 (0.61) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 | |
| SCHEMBL8395084 | 0.85 | ALDH1A1 (0.58) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 | |
| SCHEMBL13668665 | 0.84 | TPSAB1 (0.54) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 | |
| SCHEMBL1286692 | 0.84 | LMNA (0.51) | ALDH1A1LMNASMN1; SMN2TGM2F13A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | ALDH1A1 3541/4885LMNA 2226/4885SMN1; SMN2 3394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.