Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602281 | 0.86 | CCR5 (0.37) | POLBHTR7CCR5ESR1PTGS2 | |
| SCHEMBL25259307 | 0.73 | PKM (0.41) | POLBPTGS2 | |
| SCHEMBL5176206 | 0.71 | POLB (0.43) | POLBPTGS2EGFR | |
| SCHEMBL10929464 | 0.69 | ESR1 (0.38) | HTR7ESR1PTGS2 | |
| SCHEMBL5361734 | 0.68 | SMN1; SMN2 (0.38) | POLBCCR5SLC6A2SLC6A4 | |
| SCHEMBL9566865 | 0.66 | ALOX15 (0.42) | POLBCCR5 | |
| SCHEMBL20505053 | 0.65 | ALDH1A1 (0.47) | POLBESR1PTGS2SLC6A2 | |
| SCHEMBL16279674 | 0.65 | PTGS2 (0.39) | PTGS2 | |
| SCHEMBL2097425 | 0.65 | CA12 (0.52) | — | |
| SCHEMBL14808309 | 0.65 | HRH4 (0.41) | POLBCCR5ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |