Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602795 | 0.80 | ALDH1A1 (0.40) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL7589144 | 0.77 | ALDH1A1 (0.38) | ALPLALDH1A1MAPK1STAT3EPAS1 | |
| SCHEMBL6604264 | 0.77 | ALOX15 (0.41) | ALDH1A1KDM4EHPGDLMNAMAPT | |
| SCHEMBL6604272 | 0.76 | METAP2 (0.34) | EPAS1 | |
| SCHEMBL6604100 | 0.75 | PDE10A (0.47) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL6605190 | 0.73 | KDM4E (0.47) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL6603210 | 0.72 | PDE10A (0.42) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL6603724 | 0.71 | ALDH1A1 (0.39) | ALDH1A1MAPK1STAT3PDE10AKDM4E | |
| SCHEMBL7582375 | 0.71 | GAA (0.34) | ALDH1A1KDM4EHPGDMAPTHSD11B1 | |
| SCHEMBL6607597 | 0.70 | ALDH1A1 (0.38) | ALDH1A1MAPK1STAT3PDE10AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |