⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10346123 | 0.70 | BRD4 (0.43) | — | |
| SCHEMBL6603341 | 0.59 | RIPK1 (0.67) | — | |
| SCHEMBL28995640 | 0.57 | ALDH1A1 (0.50) | — | |
| SCHEMBL21444811 | 0.57 | ALDH1A1 (0.50) | — | |
| SCHEMBL3255241 | 0.56 | BCL2L1 (0.53) | — | |
| SCHEMBL24582433 | 0.54 | ALDH1A1 (0.38) | — | |
| Hydrochloric Acid SCHEMBL31751349 | 0.54 | CYP2A6 (0.52) | — | |
| SCHEMBL21689044 | 0.54 | SLC9A1 (0.39) | — | |
| SCHEMBL27018676 | 0.54 | ALOX5 (0.41) | — | |
| SCHEMBL23368535 | 0.53 | RBP4 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040204417-A1 | Novel benzothienyl or indole derivatives, preparation and use thereof as inhibitors of prenyl transferase proteins | PIERRE FABRE MEDICAMENT (FR) | 2004-10-14 | — | — | US | disclosed |
| EP-1395581-A2 | NOVEL BENZOTHIENYL OR INDOLE DERIVATIVES, PREPARATION AND USE THEREOF AS INHIBITORS OF PRENYL TRANSFERASE PROTEINS | PIERRE FABRE MEDICAMENT (FR) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002098852-A2 | NOVEL BENZOTHIENYL OR INDOLE DERIVATIVES, AND USE THEREOF AS INHIBITORS OF PRENYL TRANSFERASE PROTEINS | PIERRE FABRE MEDICAMENT (FR) | 2002-12-12 | — | — | WO | disclosed |