Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.42 |
| ▸ | PPARG | P37231 | 5/20 | 0.42 |
| ▸ | RARG | P13631 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29498841 | 1.00 | RXRA (0.42) | RXRAPPARGRARGTHRBALDH1A1 | |
| SCHEMBL1188857 | 0.87 | THRB (0.36) | RXRAPPARGRARGTHRBALDH1A1 | |
| SCHEMBL4853420 | 0.86 | RXRA (0.44) | RXRAPPARGRARGTHRBALDH1A1 | |
| SCHEMBL6473245 | 0.85 | RXRA (0.46) | RXRAPPARGRARGTHRBALDH1A1 | |
| SCHEMBL6472679 | 0.83 | THRA (0.46) | RXRAPPARGRARGTHRBALDH1A1 | |
| SCHEMBL6033258 | 0.83 | ALDH1A1 (0.36) | RXRAPPARGRARGALDH1A1CYP1A2 | |
| SCHEMBL1530388 | 0.81 | THRB (0.39) | RXRAPPARGRARGTHRBALDH1A1 | |
| SCHEMBL5086413 | 0.80 | LMNA (0.40) | RXRAPPARGRARGALDH1A1SMN1; SMN2 | |
| SCHEMBL14227116 | 0.80 | RXRA (0.43) | RXRAPPARGRARGALDH1A1SMN1; SMN2 | |
| SCHEMBL3770921 | 0.79 | CA2 (0.42) | RXRAPPARGRARGALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3911309-A1 | COMPOSITIONS AND METHODS FOR IMMUNE MODULATION AND TREATMENT OF CANCER | Board Of Trustees Of Michigan State University (US) | 2021-11-24 | — | — | EP | disclosed |
| WO-2020150668-A1 | COMPOSITIONS AND METHODS FOR IMMUNE MODULATION AND TREATMENT OF CANCER | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2020-07-23 | — | — | WO | disclosed |
| EP-1161410-B1 | RETINOID ANTAGONISTS AND USE THEREOF | BASILEA PHARMACEUTICA AG (CH) | 2004-05-12 | — | — | EP | disclosed |
| EP-1161410-A1 | RETINOID ANTAGONISTS AND USE THEREOF | Basilea Pharmaceutica AG (CH) | 2001-12-12 | — | — | EP | disclosed |
| US-6326397-B1 | OSTEOPOROSIS | HOFFMAN-LA ROCHE INC. | 2001-12-04 | — | — | US | disclosed |
| WO-2000053562-A1 | RETINOID ANTAGONISTS AND USE THEREOF | BASILEA PHARMACEUTICA AG (CH) | 2000-09-14 | — | — | WO | disclosed |