Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSG | P08311 | 6/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 6/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.43 |
| ▸ | CMA1 | P23946 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PADI1 | Q9ULC6 | 3/20 | 0.41 |
| ▸ | PADI3 | Q9ULW8 | 3/20 | 0.41 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.41 |
| ▸ | PADI2 | Q9Y2J8 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606965 | 0.87 | CTSG (0.43) | CTSGCTRB1PRSS1CMA1PADI1 | |
| SCHEMBL17731584 | 0.81 | CASP1 (0.54) | CTSLCTSK | |
| SCHEMBL6607345 | 0.81 | CASP3 (0.48) | PADI1PADI3PADI4PADI2PDE4A | |
| SCHEMBL8972436 | 0.80 | RAB9A (0.52) | CTSGCTRB1PRSS1CMA1SMN1; SMN2 | |
| SCHEMBL18103838 | 0.76 | KLK5 (0.58) | CTSLCTSK | |
| SCHEMBL29946196 | 0.76 | KLK5 (0.58) | CTSLCTSK | |
| SCHEMBL10561618 | 0.75 | P2RY12 (0.43) | CTSGCTRB1PRSS1CMA1CTSL | |
| SCHEMBL10977546 | 0.74 | ACE (0.49) | CTSLALDH1A1CTSK | |
| SCHEMBL15662393 | 0.74 | EPHX2 (0.42) | PTPRC | |
| SCHEMBL6496041 | 0.74 | ACE (0.64) | CTSGCTRB1CMA1CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163208-B1 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6632962-B2 | N-(2-carboxy-1-haloacetylethyl)arylamide derivatives as inhibitors of caspase and cellular apoptosis. | VERTEX PHARMACEUTICALS INCORPORATED | 2003-10-14 | — | — | US | disclosed |
| US-20020132833-A1 | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2002-09-19 | — | — | US | disclosed |
| EP-1163208-A4 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2002-07-03 | — | — | EP | disclosed |
| EP-1163208-A2 | CASPASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2001010383-A2 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020132833-A1 | Caspase inhibitors and uses thereof | CASP1, CASP3, CASP7 | CTSG 216/4885CTRB1 259/4885PRSS1 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.