Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614053 | 0.90 | ALOX15 (0.41) | ALOX15ACHEALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL6614279 | 0.88 | ALOX15 (0.51) | ALOX15ACHEALDH1A1MAPTBCHE | |
| SCHEMBL6610853 | 0.86 | ALOX15 (0.45) | ALOX15ACHEALDH1A1MAPTBCHE | |
| SCHEMBL5841640 | 0.86 | ALOX15 (0.52) | ALOX15ALDH1A1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL6613841 | 0.84 | ALDH1A1 (0.39) | ALDH1A1MAPTSMN1; SMN2NPSR1KDM4E | |
| SCHEMBL6609399 | 0.82 | ALDH1A1 (0.41) | ALDH1A1MAPTSMN1; SMN2NPSR1KDM4E | |
| SCHEMBL6615359 | 0.82 | MAPT (0.39) | ALDH1A1HCRTR1HCRTR2MAPTSMN1; SMN2 | |
| SCHEMBL6609500 | 0.82 | ALOX15 (0.50) | ALOX15ACHEALDH1A1MAPTBCHE | |
| SCHEMBL6613611 | 0.81 | ACHE (0.42) | ACHEALDH1A1MAPTBCHESMN1; SMN2 | |
| SCHEMBL6609870 | 0.81 | ALOX15 (0.55) | ALOX15ACHEALDH1A1MAPTBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |