Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613841 | 0.91 | ALDH1A1 (0.39) | MAPTNPSR1HPGDKDM4EALDH1A1 | |
| SCHEMBL6609690 | 0.90 | CRHR1 (0.38) | MAPTNPSR1HPGDKDM4EALDH1A1 | |
| SCHEMBL6617034 | 0.88 | MTNR1A (0.46) | MAPTNPSR1HPGDKDM4EALDH1A1 | |
| SCHEMBL5842942 | 0.87 | MAPT (0.53) | MAPTNPSR1HPGDKDM4EALDH1A1 | |
| SCHEMBL6610719 | 0.86 | SLC2A1 (0.45) | MAPTNPSR1HPGDKDM4EALDH1A1 | |
| SCHEMBL6609900 | 0.82 | ALOX15 (0.43) | MAPTNPSR1HPGDKDM4EALDH1A1 | |
| SCHEMBL6612072 | 0.81 | MTNR1A (0.40) | MAPTNPSR1HPGDKDM4EALDH1A1 | |
| SCHEMBL6612194 | 0.81 | MAPT (0.39) | MAPTNPSR1HPGDKDM4EALDH1A1 | |
| SCHEMBL6611071 | 0.81 | MAPT (0.43) | MAPTNPSR1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6609399 | 0.81 | ALDH1A1 (0.41) | MAPTNPSR1HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | claimed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | claimed |
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |