Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.42 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611410 | 0.89 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6608839 | 0.87 | BCHE (0.50) | ACHEBCHEALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6609671 | 0.86 | BCHE (0.47) | ACHEBCHEALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6610605 | 0.85 | ACHE (0.49) | ACHEBCHEALDH1A1MAPTHPGD | |
| SCHEMBL5844187 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPTHPGDSMN1; SMN2KDM4E | |
| SCHEMBL6609399 | 0.82 | ALDH1A1 (0.41) | ALDH1A1MAPTHPGDSMN1; SMN2USP2 | |
| SCHEMBL6614115 | 0.82 | ALDH1A1 (0.49) | BCHEALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL6609900 | 0.81 | ALOX15 (0.43) | ACHEBCHEALDH1A1MAPTHPGD | |
| SCHEMBL6612851 | 0.80 | SMN1; SMN2 (0.42) | BCHEALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL6613841 | 0.80 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDSMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |