SCHEMBL6610135

SCHEMBL6610135

N#Cc1c2c(nc3ccccc13)NCCC2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.51
ALDH1A1 P00352 4/20 0.51
BCHE P06276 3/20 0.43
LMNA P02545 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.39
POLB P06746 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
UHRF1 Q96T88 1/20 0.39
MAPK1 P28482 1/20 0.39
CASP1 P29466 1/20 0.39
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 2/20 0.38
THRB P10828 1/20 0.38
MEN1 O00255 1/20 0.38
RAB9A P51151 1/20 0.38
GFER P55789 1/20 0.38
KMT2A Q03164 1/20 0.38
HSD17B10 Q99714 3/20 0.37
ADORA2A P29274 1/20 0.37
ACHE P22303 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9851400 0.78 BCHE (0.63) KDM4EALDH1A1BCHELMNASMN1; SMN2
Hydrochloric Acid SCHEMBL9851368 0.72 BCHE (0.61) KDM4EALDH1A1BCHELMNASMN1; SMN2
SCHEMBL2001240 0.70 KDM4E (1.00) KDM4EALDH1A1LMNASMN1; SMN2POLB
SCHEMBL3562426 0.68 ACHE (0.61) KDM4EALDH1A1BCHELMNASMN1; SMN2
SCHEMBL18369695 0.67 UHRF1 (0.46) KDM4EALDH1A1SMN1; SMN2POLBNPSR1
Bromide SCHEMBL9851359 0.67 ACHE (0.59) KDM4EALDH1A1BCHELMNASMN1; SMN2
SCHEMBL9599079 0.67 KDM4E (0.53) KDM4EALDH1A1BCHELMNASMN1; SMN2
SCHEMBL10379077 0.65 UHRF1 (0.40) KDM4EALDH1A1BCHEPOLBUHRF1
SCHEMBL6059433 0.63 ALDH1A1 (0.68) KDM4EALDH1A1CYP1A2MEN1KMT2A
SCHEMBL9098370 0.63 RAB9A (0.43) KDM4EALDH1A1SMN1; SMN2UHRF1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1379248-A1 TRICYCLIC COMPOUNDS USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-01-14 EP claimed
WO-2002085365-A1 TRICYCLIC COMPOUNDS USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-31 WO claimed
EP-1379248-A1 TRICYCLIC COMPOUNDS USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-01-14 EP disclosed
WO-2002085365-A1 TRICYCLIC COMPOUNDS USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-31 WO disclosed