Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614708 | 0.93 | CCR5 (0.47) | LMNACYP2D6TSHRMAPTKMT2A | |
| SCHEMBL6613155 | 0.92 | CCR5 (0.51) | LMNACYP2D6MAPTKMT2ASIGMAR1 | |
| SCHEMBL6611611 | 0.91 | CCR5 (0.52) | LMNACYP2D6MAPTKMT2ASIGMAR1 | |
| SCHEMBL6614322 | 0.91 | CCR5 (0.52) | LMNACYP2D6MAPTKMT2ASIGMAR1 | |
| SCHEMBL6612781 | 0.89 | LMNA (0.53) | LMNACYP2D6CHRM2ADRA2ATSHR | |
| SCHEMBL6615053 | 0.88 | OPRL1 (0.55) | CHRM2SIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6612028 | 0.87 | LMNA (0.51) | LMNACYP2D6CHRM2ADRA2ATSHR | |
| SCHEMBL6611036 | 0.85 | CCR5 (0.52) | LMNACYP2D6CHRM2ADRA2ATSHR | |
| SCHEMBL6614791 | 0.84 | OPRM1 (0.42) | LMNACYP2D6MAPTKMT2AL3MBTL1 | |
| SCHEMBL6613037 | 0.84 | SIGMAR1 (0.49) | LMNACYP2D6CHRM2ADRA2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1236726-B1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1236726-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-09-04 | — | — | EP | disclosed |