Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616448 | 0.94 | EPHX2 (0.40) | HRH3EPHX2SSTR3PAX8ACKR3 | |
| SCHEMBL6621042 | 0.93 | ACKR3 (0.40) | ACKR3PKMPPARGLMNAHSD11B1 | |
| SCHEMBL6683281 | 0.92 | MAPT (0.40) | HRH3EPHX2PAX8PKMRAB9A | |
| SCHEMBL6616443 | 0.92 | CRACR2A (0.42) | HRH3PAX8PTGESMAPT | |
| SCHEMBL6619848 | 0.92 | PPARG (0.42) | ACKR3PKMRAB9APPARGMAPT | |
| SCHEMBL6618455 | 0.92 | LMNA (0.39) | ACKR3LMNAMAPT | |
| SCHEMBL6617068 | 0.90 | PKM (0.38) | ACKR3PKMRAB9APTGESLMNA | |
| SCHEMBL6617585 | 0.90 | ALDH1A1 (0.43) | ACKR3RAB9ALMNATP53MAPT | |
| SCHEMBL6620593 | 0.88 | HRH3 (0.39) | HRH3EPHX2ACKR3RAB9ACNR1 | |
| SCHEMBL6615915 | 0.88 | PAX8 (0.49) | PAX8RAB9ALMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |